Department of Cardiology, Panyu Central Hospital; Cardiovascular Institute of Panyu District; School of Life Sciences, South China Normal University, Guangzhou.
School of Life Sciences, South China Normal University, Guangzhou .
Eur J Histochem. 2020 Jul 30;64(s2):3142. doi: 10.4081/ejh.2020.3142.
Acute myocardial infarction (AMI) is recognized to be a severe threat to people's health conditions and life quality. The accumulation of hepatocyte growth factor (HGF) in ischemic myocardium has been observed in both processes of experimental ischemia and reperfusion (I/R) and permanent coronary artery occlusion. The aim of the study was to investigate the effect of HGF on myocardial cell apoptosis, ventricular remodeling and cardiac function after myocardial infarction (MI) in diabetic rats, and to explore whether the effect is mediated by HGF/c-Met signaling pathway. MI significantly increases LVWI and RVWI and myocardial apoptotic index, and up-regulates the expression of HGF and c-Met at mRNA and protein levels in MI control group. The LVWI and RVWI, and myocardial apoptosis were reduced by treatment with HGF, which also increased the myocardial cell viability and the expression of HGF and c-Met. In summary, HGF significantly attenuates myocardial apoptosis and improves cardiac function after AMI in diabetic rats by further enhancing the activation of HGF/c-Met pathway.
急性心肌梗死（AMI）被认为是严重威胁人们健康状况和生活质量的疾病。在实验性缺血再灌注（I/R）和永久性冠状动脉闭塞过程中，均观察到缺血心肌中肝细胞生长因子（HGF）的积累。本研究旨在探讨 HGF 对糖尿病大鼠心肌梗死后心肌细胞凋亡、心室重构和心功能的影响，并探讨其是否通过 HGF/c-Met 信号通路介导。心肌梗死显著增加 LVWI 和 RVWI 以及心肌细胞凋亡指数，并在 MI 对照组中上调 HGF 和 c-Met 的 mRNA 和蛋白水平表达。HGF 治疗可降低 LVWI 和 RVWI 以及心肌细胞凋亡，同时增加心肌细胞活力和 HGF 和 c-Met 的表达。综上所述，HGF 通过进一步增强 HGF/c-Met 通路的激活，显著减轻糖尿病大鼠 AMI 后的心肌细胞凋亡，改善心功能。
