昼夜节律钟基因与 2 型糖尿病患者的心肌梗死。
Circadian clock genes and myocardial infarction in patients with type 2 diabetes mellitus.
机构信息
Department of Biology, Faculty of Dental Medicine and Health, J. J. Strossmayer University of Osijek, Croatia; Faculty of Medicine, J. J. Strossmayer University of Osijek, Croatia.
Faculty of Medicine, J. J. Strossmayer University of Osijek, Croatia.
出版信息
Gene. 2019 Jun 15;701:98-103. doi: 10.1016/j.gene.2019.03.038. Epub 2019 Mar 21.
Disruption of circadian clock may trigger the onset of diabetes mellitus and myocardial infarction. Type 2 diabetes mellitus (T2DM) is well-known risk factors for cardiovascular diseases and myocardial infarction. We performed a case-control study, where we explored the possible association between single nucleotide polymorphisms in three circadian rhythm genes (ARNTL, CLOCK, and PER2) and myocardial infarction in 657 patients with T2DM. The study group consisted of 231 patients with myocardial infarction and T2DM and a control group of 426 T2DM patients. We hypothesized that variations in the circadian rhythm genes in patients with T2DM could be an additional risk factor for myocardial infarction. The statistically significant difference was found in allelic (p = 1.1 × 10-5) and genotype distribution (p = 1.42 × 10-4) between two groups of the rs12363415 at the ARNTL gene locus. We provide evidence that genetic variability in the ARNTL gene might be associated with myocardial infarction in patients with T2DM.
生物钟紊乱可能引发糖尿病和心肌梗死的发生。2 型糖尿病（T2DM）是心血管疾病和心肌梗死的已知危险因素。我们进行了一项病例对照研究，探讨了三个生物钟基因（ARNTL、CLOCK 和 PER2）中的单核苷酸多态性与 657 例 T2DM 患者心肌梗死之间的可能关联。研究组包括 231 例心肌梗死合并 T2DM 患者和 426 例 T2DM 患者对照组。我们假设 T2DM 患者生物钟基因的变异可能是心肌梗死的另一个危险因素。在 ARNTL 基因座的 rs12363415 中，我们发现等位基因（p=1.1×10-5）和基因型分布（p=1.42×10-4）在两组之间存在统计学显著差异。我们提供的证据表明，ARNTL 基因的遗传变异可能与 T2DM 患者的心肌梗死有关。
Zotero 插件