CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.
University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.
J Org Chem. 2020 Oct 2;85(19):12754-12759. doi: 10.1021/acs.joc.0c01407. Epub 2020 Sep 10.
Two pairs of salicylaldehyde derivative enantiomers, euroticins A and B ( and ), were isolated from a marine-derived fungus sp. SCSIO F452. Compound possesses a highly constructed 6/6/6/5/7 pentacyclic structure featuring an unprecedented 2,11-dioxatricyclo[5.3.1.0]undecane core. Compound represents the first example of 6/6/6/6 tetracyclic salicylaldehyde derivative. Their structures were established by spectroscopic analyses, X-ray diffraction, and electronic circular dichroism (ECD) and C NMR calculations. Compounds (+)- and (-)- exhibited remarkable antioxidative activities.
从海洋来源真菌 sp. SCSIO F452 中分离得到了两对水杨醛衍生物对映异构体，欧前胡素 A 和 B（和）。化合物 具有高度构建的 6/6/6/5/7 五环骨架，具有前所未有的 2,11-二氧杂三环[5.3.1.0]十一烷核。化合物 代表了第一个 6/6/6/6 四环水杨醛衍生物的例子。它们的结构通过光谱分析、X 射线衍射以及电子圆二色性（ECD）和 13C NMR 计算确定。化合物 (+)-和 (-)-表现出显著的抗氧化活性。
