从海洋来源真菌 sp. SCSIO F452 中分离得到的五个新生物碱 Eurotiumins A⁻E。

Eurotiumins A⁻E, Five New Alkaloids from the Marine-Derived Fungus sp. SCSIO F452.

机构信息

CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.

University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China.

出版信息

Mar Drugs. 2018 Apr 21;16(4):136. doi: 10.3390/md16040136.

Three new prenylated indole 2,5-diketopiperazine alkaloids (⁻) with nine known ones (⁻), one new indole alkaloid (), and one new bis-benzyl pyrimidine derivative () were isolated and characterized from the marine-derived fungus sp. SCSIO F452. and , occurring as a pair of diastereomers, both presented a hexahydropyrrolo[2,3-]indole skeleton. Their chemical structures, including absolute configurations, were elucidated by 1D and 2D NMR, HRESIMS, quantum chemical calculations of electronic circular dichroism, and single crystal X-ray diffraction experiments. Most isolated compounds were screened for antioxidative potency. Compounds , , , , , , and showed significant radical scavenging activities against DPPH with IC values of 13, 19, 4, 3, 24, 13, and 18 µM, respectively. Five new compounds were evaluated for cytotoxic activities.

从海洋来源真菌 sp. SCSIO F452 中分离得到三个新的prenylated indole 2,5-diketopiperazine 生物碱（⁻）和九个已知的（⁻），一个新的吲哚生物碱（）和一个新的双苄基嘧啶衍生物（）。和，作为一对非对映异构体存在，两者均呈现出 hexahydropyrrolo[2,3-]indole 骨架。通过 1D 和 2D NMR、HRESIMS、电子圆二色谱的量子化学计算和单晶 X 射线衍射实验，阐明了它们的化学结构，包括绝对构型。对大多数分离得到的化合物进行了抗氧化活性筛选。化合物、、、、、和对 DPPH 具有显著的自由基清除活性，IC 值分别为 13、19、4、3、24、13 和 18 μM。对五个新化合物进行了细胞毒性活性评价。