Department of Clinical Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Department of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Int J Cancer. 2021 Feb 15;148(4):1006-1013. doi: 10.1002/ijc.33291. Epub 2020 Oct 5.
Pancreatic cancer has a low survival rate, and most patients have lymph node metastasis and distant metastasis at the time of diagnosis. Despite efforts to improve overall survival (OS) and recurrence free survival (RFS), the prognosis of pancreatic cancer remains poor, underscoring the importance of identifying new biomarkers to predict metastasis in patients with pancreatic cancer. Leukemia inhibitory factor (LIF) is overexpressed in many types of cancer and is involved in the development of various malignancies including pancreatic cancer. However, the role of LIF as a biomarker to predict metastasis in pancreatic cancer remains unclear. In this study, univariate and multivariate Cox regression analyses identified LIF expression in pancreatic tumor tissues as an independent risk factor related to worse OS and RFS. LIF overexpression was related to poor clinicopathological features such as lymph node metastasis and Pathological stage (pTNM) stage. Serum LIF levels were higher in pancreatic cancer patients than in healthy controls. The area under the receiver operating characteristic curve indicated that serum LIF is more effective than other biomarkers (CA199 and CEA) for predicting lymph node and distant metastasis.
胰腺癌的存活率较低，大多数患者在诊断时已发生淋巴结转移和远处转移。尽管为提高总生存期 (OS) 和无复发生存期 (RFS) 做出了努力，但胰腺癌的预后仍然较差，这突显了确定新的生物标志物来预测胰腺癌患者转移的重要性。白血病抑制因子 (LIF) 在多种癌症中过度表达，与包括胰腺癌在内的多种恶性肿瘤的发展有关。然而，LIF 作为预测胰腺癌转移的生物标志物的作用尚不清楚。在这项研究中，单因素和多因素 Cox 回归分析确定胰腺肿瘤组织中 LIF 表达是与较差的 OS 和 RFS 相关的独立危险因素。LIF 过表达与淋巴结转移和病理分期 (pTNM 分期) 等不良临床病理特征相关。胰腺癌患者的血清 LIF 水平高于健康对照组。受试者工作特征曲线下面积表明，血清 LIF 预测淋巴结和远处转移的效果优于其他标志物 (CA199 和 CEA)。
