COVID-19 患者嗅觉丧失：MRI 数据显示嗅裂短暂性水肿。
Loss of smell in patients with COVID-19: MRI data reveal a transient edema of the olfactory clefts.
机构信息
From the Department of Neuroradiology (M.E., E.H.) and Department of Head and Neck Surgery (A.-L.H., P.H., J.H., C.J., C.E., B.V., C.H.), Lariboisière University Hospital, Paris, France.
出版信息
Neurology. 2020 Dec 8;95(23):e3145-e3152. doi: 10.1212/WNL.0000000000010806. Epub 2020 Sep 11.
OBJECTIVE
To assess the physiopathology of olfactory function loss (OFL) in patients with coronavirus disease 2019 (COVID-19), we evaluated the olfactory clefts (OC) on MRI during the early stage of the disease and 1 month later.
METHODS
This was a prospective, monocentric, case-controlled study. Twenty severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-infected patients with OFL were included and compared to 20 age-matched healthy controls. All infected patients underwent olfactory function assessment and 3T MRI, performed both at the early stage of the disease and at the 1-month follow-up.
RESULTS
At the early stage, SARS-CoV2-infected patients had a mean olfactory score of 2.8 ± 2.7 (range 0-8), and MRI displayed a complete obstruction of the OC in 19 of 20 patients. Controls had normal olfactory scores and no obstruction of the OC on MRI. At the 1 month follow-up, the olfactory score had improved to 8.3 ± 1.9 (range 4-10) in patients, and only 7 of 20 patients still had an obstruction of the OC. There was a correlation between olfactory score and obstruction of the OC ( = 0.004).
CONCLUSION
OFL in SARS-CoV2-infected patients is associated with a reversible obstruction of the OC.
目的
评估 2019 年冠状病毒病（COVID-19）患者嗅觉功能丧失（OFL）的病理生理学，我们在疾病早期和 1 个月后评估了 MRI 中的嗅裂（OC）。
方法
这是一项前瞻性、单中心、病例对照研究。纳入了 20 名 SARS-CoV2 感染且存在 OFL 的严重急性呼吸综合征冠状病毒 2（SARS-CoV2）感染患者，并与 20 名年龄匹配的健康对照进行了比较。所有感染患者均接受了嗅觉功能评估和 3T MRI，分别在疾病早期和 1 个月随访时进行。
结果
在早期，SARS-CoV2 感染患者的平均嗅觉评分为 2.8 ± 2.7（范围 0-8），MRI 显示 20 名患者中有 19 名 OC 完全阻塞。对照组的嗅觉评分正常，MRI 无 OC 阻塞。在 1 个月的随访中，患者的嗅觉评分改善至 8.3 ± 1.9（范围 4-10），只有 7 名患者仍有 OC 阻塞。嗅觉评分与 OC 阻塞之间存在相关性（ = 0.004）。
结论
SARS-CoV2 感染患者的 OFL 与 OC 的可逆阻塞有关。
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