Wan Jinzhao, Wang Xiaoxiong, Zhen Yunbo, Chen Xin, Yao Penglei, Liu Wenwu, Lu Enzhou, Du Yiming, Liu Huailei, Zhao Shiguang
Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, 150001 Heilongjiang Province People's Republic of China.
Institute of Brain Science, Harbin Medical University, No. 23 Youzheng Street, Nangang District, Harbin, 150001 Heilongjiang Province People's Republic of China.
Chin Neurosurg J. 2020 Jul 1;6:22. doi: 10.1186/s41016-020-00201-5. eCollection 2020.
Our study aimed to determine the effect of the neutrophil-lymphocyte ratio on the prognosis of adult patients with acute stroke. We searched the Web of Science, PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure databases and selected all of the potentially eligible studies. From the included studies, we extracted characteristics such as the stroke type and acquisition time until routine blood collection and the odds ratios across studies. The 95% confidence intervals and odds ratios were pooled to calculate the effect size for the neutrophil-lymphocyte ratio in acute stroke patients. We defined poor function outcomes according to the modified Rankin Scale ≥ 3 or Glasgow Outcome Scale< 3.Thirteen studies with 4443 patients were included in our analysis, including 7 ischemic and 6 hemorrhagic stroke studies. The pooled odds ratios for poor functional outcome at 3 months with a higher neutrophil-lymphocyte ratio in acute ischemic and hemorrhagic patients were 1.689 (95% CI = 1.184-2.409, < 0.001) and 1.125 (95% CI = 1.022-1.239, < 0.001), respectively, and the overall pooled odds ratio for poor functional outcome following stroke was 1.257 (95% CI = 1.146-1.379, < 0.001). At the same time, the overall combined odds ratio for death at 3 months was 1.632 (95% CI = 1.155-2.306, < 0.001).The neutrophil-lymphocyte ratio, an easily calculated marker, plays a predictive role in the short-term outcomes of adult patients (mean age ≥ 50 years) following acute ischemic and hemorrhagic stroke.
我们的研究旨在确定中性粒细胞与淋巴细胞比值对成年急性中风患者预后的影响。我们检索了科学网、PubMed、Embase、Cochrane图书馆和中国知网数据库，并筛选了所有可能符合条件的研究。从纳入的研究中，我们提取了中风类型、常规血液采集前的采集时间以及各研究的比值比等特征。汇总95%置信区间和比值比，以计算急性中风患者中性粒细胞与淋巴细胞比值的效应量。我们根据改良Rankin量表≥3或格拉斯哥预后量表<3来定义功能预后不良。我们的分析纳入了13项研究，共4443例患者，其中包括7项缺血性中风研究和6项出血性中风研究。急性缺血性和出血性中风患者中性粒细胞与淋巴细胞比值较高时，3个月时功能预后不良的汇总比值比分别为1.689（95%置信区间=1.184-2.409，P<0.001）和1.125（95%置信区间=1.02-1.239，P<0.001），中风后功能预后不良的总体汇总比值比为1.257（95%置信区间=1.146-1.379，P<0.001）。同时，3个月时死亡的总体合并比值比为1.632（95%置信区间=1.155-2.306，P<0.001）。中性粒细胞与淋巴细胞比值是一个易于计算的指标，对成年（平均年龄≥50岁）急性缺血性和出血性中风患者的短期预后具有预测作用。
