Xu Donghan, Wang Lizhen, Deng Lu, Luo Yehao, Wei Yan, Yan Peiyu
Macau University of Science and Technology, College of Traditional Chinese Medicine, Macau.
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province.
Medicine (Baltimore). 2020 Sep 11;99(37):e22188. doi: 10.1097/MD.0000000000022188.
Primary dysmenorrhea (PD) is one of the common gynecological diseases, the incidence of PD is on the rise and young women are more likely to have it, which seriously affects women's physical, mental health and work life. Intradermal acupuncture is effective in treating PD. However, due to the lack of evidence, there is no specific method or suggestion, so it is necessary to carry out systematic evaluation on intradermal acupuncture and provide effective evidence for further research.
We will search the following electronic databases from their inception to July 2020: Electronic database includes PubMed, Embase, Cochrane Library, Chinese Biomedical Database WangFang, VIP medicine information, and CNKI (China National Knowledge Infrastructure). Primary outcomes: the overall effective rate, VAS score.
blood serum estradiol (E2), progesterone (P), prostaglandin F2α (PGF-2α), adverse events Data will be extracted by 2 researchers independently, risk of bias of the meta-analysis will be evaluated based on the Cochrane Handbook for Systematic Reviews of Interventions. All data analysis will be conducted by data statistics software Review Manager V.5.3. and Stata V.12.0.
The results of this study will systematically evaluate the effectiveness and safety of intradermal acupuncture in the treatment of primary dysmenorrhea.
The systematic review of this study will summarize the currently published evidence of intradermal acupuncture therapy for primary dysmenorrhea to further guide its promotion and application.
原发性痛经（PD）是常见的妇科疾病之一，其发病率呈上升趋势，且年轻女性更易患病，严重影响女性身心健康及工作生活。皮内针疗法治疗PD有效。然而，由于缺乏证据，尚无具体方法或建议，因此有必要对皮内针疗法进行系统评价，为进一步研究提供有效依据。
我们将检索以下电子数据库自建库至2020年7月的数据：电子数据库包括PubMed、Embase、Cochrane图书馆、中国生物医学数据库万方、维普医药信息和中国知网（CNKI）。主要结局指标：总有效率、视觉模拟评分（VAS）。
血清雌二醇（E2）、孕酮（P）、前列腺素F2α（PGF-2α）、不良事件。数据将由2名研究人员独立提取，基于Cochrane系统评价干预措施手册对荟萃分析的偏倚风险进行评估。所有数据分析将使用数据统计软件Review Manager V.5.3和Stata V.12.0进行。
本研究结果将系统评价皮内针疗法治疗原发性痛经的有效性和安全性。
本研究的系统评价将总结目前已发表的皮内针疗法治疗原发性痛经的证据，以进一步指导其推广应用。
