Department of Cell Biology and Neuroscience, Montana State University, Bozeman, Montana.
Semin Neurol. 2020 Oct;40(5):473-484. doi: 10.1055/s-0040-1713926. Epub 2020 Sep 14.
Investigations of the cellular and molecular mechanisms that mediate the development of the autonomic nervous system have identified critical genes and signaling pathways that, when disrupted, cause disorders of the autonomic nervous system. This review summarizes our current understanding of how the autonomic nervous system emerges from the organized spatial and temporal patterning of precursor cell migration, proliferation, communication, and differentiation, and discusses potential clinical implications for developmental disorders of the autonomic nervous system, including familial dysautonomia, Hirschsprung disease, Rett syndrome, and congenital central hypoventilation syndrome.
研究调节自主神经系统发育的细胞和分子机制已经确定了一些关键基因和信号通路，当这些基因和信号通路发生异常时，会导致自主神经系统紊乱。这篇综述总结了我们目前对于自主神经系统如何从前体细胞的迁移、增殖、通讯和分化的有序时空模式中出现的理解，并讨论了自主神经系统发育障碍的潜在临床意义，包括家族性自主神经异常、先天性巨结肠、雷特综合征和先天性中枢性低通气综合征。
