2019冠状病毒病患者的嗅觉障碍：一项系统文献综述
Olfactory disorders in coronavirus disease 2019 patients: a systematic literature review.
作者信息
Fuccillo E, Saibene A M, Canevini M P, Felisati G
机构信息
Department of Clinical Sciences and Translational Medicine, 'Tor Vergata' University of Rome, Italy.
Department of Health Sciences, University of Milan, Italy.
出版信息
J Laryngol Otol. 2020 Sep 15:1-10. doi: 10.1017/S0022215120002005.
OBJECTIVE
Recent scientific literature has widely described a possible major role of smell dysfunction as a specific symptom of coronavirus disease 2019. This systematic review may provide a more holistic approach to current knowledge of the disease.
METHODS
A systematic review was completed using Embase, PubMed and Web of Science databases that considered original articles focused on olfactory evaluation in coronavirus disease 2019 patients, published between March and May 2020, in English language.
RESULTS
From the 483 research papers initially identified, 32 original studies were selected, comprising a total of 17 306 subjects with a laboratory confirmed diagnosis of coronavirus disease 2019. Individual study sample sizes ranged from 6 to 6452 patients. This comprehensive analysis confirmed that olfactory disorders represent an important clinical feature in coronavirus disease 2019, with a prevalence of 11-100 per cent in included patients, although there was heterogeneity in terms of assessment tools and population selection criteria.
CONCLUSION
The results indicate that an accurate clinical evaluation should be carried out using structured questionnaires and tests with olfactory substances.
目的
近期科学文献广泛描述了嗅觉功能障碍作为2019冠状病毒病的一种特定症状可能发挥的主要作用。本系统评价可为当前对该疾病的认识提供一种更全面的方法。
方法
利用Embase、PubMed和Web of Science数据库完成了一项系统评价，纳入了2020年3月至5月间发表的、聚焦于2019冠状病毒病患者嗅觉评估的英文原创文章。
结果
从最初确定的483篇研究论文中，筛选出32项原创研究，共计17306名经实验室确诊为2019冠状病毒病的受试者。单项研究的样本量从6名至6452名患者不等。这项综合分析证实，嗅觉障碍是2019冠状病毒病的一项重要临床特征，在所纳入患者中的患病率为11%至100%，不过在评估工具和人群选择标准方面存在异质性。
结论
结果表明，应使用结构化问卷和嗅觉物质测试进行准确的临床评估。
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