Department of Otolaryngology - Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Department of Otorhinolaryngology - Head and Neck Surgery, Meir Medical Center, Kfar-Saba, Israel.
J Laryngol Otol. 2023 Nov;137(11):1256-1260. doi: 10.1017/S0022215123000713. Epub 2023 May 17.
To investigate the clinical features, therapeutic efficacy and symptom time course of post-coronavirus disease 2019 parosmia.
A 22-item online questionnaire was distributed to AbScent research group and Facebook coronavirus disease 2019 anosmia group adult members to assess clinical features, interventions and their subjective efficacy for parosmia.
A total of 209 participants (86 per cent females) reported: smell loss on average 3 days after coronavirus symptoms, recovery 4 weeks later, and first parosmia symptoms 12 weeks post infection. Respondents reported 10 per cent body weight loss, and listed onion and garlic as significant parosmia triggers. Regarding quality of life, depression was the most cited item (54 per cent). Smell training was trialled by 74 per cent of participants, followed by nasal corticosteroid spray (49 per cent). Stellate ganglion block, trialled by 16 per cent of respondents, had the highest reported improvement (45 per cent), with 21 per cent reporting a sustained benefit - the highest rate amongst registered treatment options.
Post-coronavirus parosmia has a significant impact and remains challenging to treat. Stellate ganglion block appears to be successful relative to other reported treatments. Further research into the pathophysiology, efficacy and mechanism of stellate ganglion block effect is warranted.
研究新冠病毒感染后嗅觉障碍（post-coronavirus disease 2019 parosmia，PCDP）的临床特征、治疗效果及症状进展过程。
通过 AbScent 研究小组和 Facebook 新冠病毒嗅觉丧失群组向成年成员发放了一份包含 22 个问题的在线问卷，以评估 PCDP 的临床特征、干预措施及其主观疗效。
共有 209 名参与者（86%为女性）报告称：平均在冠状病毒症状出现后 3 天出现嗅觉丧失，4 周后恢复，感染后 12 周出现首次嗅觉障碍症状。参与者报告体重减轻了 10%，并将洋葱和大蒜列为主要嗅觉障碍触发因素。在生活质量方面，抑郁是最常被提及的项目（54%）。74%的参与者尝试了嗅觉训练，其次是鼻用皮质类固醇喷雾（49%）。16%的受访者尝试了星状神经节阻滞，报告的改善率最高（45%），21%的人报告持续获益——这是登记治疗方案中最高的获益率。
新冠病毒感染后嗅觉障碍对患者的影响较大，治疗仍具挑战性。与其他报道的治疗方法相比，星状神经节阻滞似乎更有效。有必要进一步研究星状神经节阻滞的病理生理学、疗效和作用机制。
