Department of Biotechnology, Indian Institute of Technology Roorkee , Roorkee, India.
Hum Vaccin Immunother. 2020 Dec 1;16(12):2921-2931. doi: 10.1080/21645515.2020.1805992. Epub 2020 Sep 15.
The sudden emergence of a highly transmissible and pathogenic coronavirus SARS-CoV-2 in December 2019 from China and its rapid global spread has posed an international health emergency. The rapid development of an effective vaccine is imperative to control the spread of SARS-CoV-2. A number of concurrent efforts to find an effective therapeutic agent or vaccine for COVID-19 (coronavirus disease 2019) are being undertaken globally. Oral and nasal mucosal surfaces serve as the primary portal of entry for pathogens like coronaviruses in the human body. As evidenced by studies on similar coronaviruses (SARS-CoV and MERS-CoV), mucosal vaccination can provide a safe and effective means for the induction of long-lasting systemic and mucosal immunity to confer protection against SARS-CoV-2. This article summarizes the approaches to an effective mucosal vaccine formulation which can be a rewarding approach to combat the unprecedented threat posed by this emerging global pandemic.
2019 年 12 月，一种高传染性和致病性的冠状病毒 SARS-CoV-2 突然在中国出现，并迅速在全球范围内传播，这构成了国际卫生紧急事件。快速开发有效的疫苗对于控制 SARS-CoV-2 的传播至关重要。目前，全球正在进行许多旨在寻找 COVID-19（2019 年冠状病毒病）有效治疗药物或疫苗的同步努力。口腔和鼻腔黏膜表面是人体中冠状病毒等病原体进入的主要门户。类似的冠状病毒（SARS-CoV 和 MERS-CoV）的研究表明，黏膜疫苗接种可为诱导针对 SARS-CoV-2 的长期全身和黏膜免疫提供一种安全有效的手段，从而提供保护。本文总结了有效的黏膜疫苗配方方法，这可能是应对这一新兴全球大流行所带来的前所未有的威胁的一种有价值的方法。
