Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.
School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.
Sensors (Basel). 2024 Feb 2;24(3):985. doi: 10.3390/s24030985.
In this study, a novel electrochemical sensor was created by fabricating a screen-printed carbon electrode with diamond nanoparticles (DNPs/SPCE). The successful development of the sensor enabled the specific detection of the anti-cancer drug flutamide (FLT). The DNPs/SPCE demonstrated excellent conductivity, remarkable electrocatalytic activity, and swift electron transfer, all of which contribute to the advantageous monitoring of FLT. These qualities are critical for monitoring FLT levels in environmental samples. Various structural and morphological characterization techniques were employed to validate the formation of the DNPs. Remarkably, the electrochemical sensor demonstrated a wide linear response range (0.025 to 606.65 μM). Additionally, it showed a low limit of detection (0.023 μM) and high sensitivity (0.403 μA μM cm). Furthermore, the practicability of DNPs/SPCE can be successfully employed in FLT monitoring in water bodies (pond water and river water samples) with satisfactory recoveries.
在这项研究中，通过制备带有金刚石纳米粒子（DNPs/SPCE）的丝网印刷碳电极，创建了一种新型电化学传感器。该传感器的成功开发实现了对抗癌药物氟他胺（FLT）的特异性检测。DNPs/SPCE 表现出优异的导电性、显著的电催化活性和快速的电子转移，所有这些都有助于对 FLT 的有利监测。这些特性对于监测环境样品中的 FLT 水平至关重要。各种结构和形态特征化技术被用于验证 DNPs 的形成。值得注意的是，电化学传感器表现出宽的线性响应范围（0.025 至 606.65 μM）。此外，它还表现出低的检测限（0.023 μM）和高灵敏度（0.403 μA μM cm）。此外，DNPs/SPCE 的实用性可以成功地应用于水体（池塘水和河水样本）中 FLT 的监测，具有令人满意的回收率。
