Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Daejeon St. Mary Mary's Hospital, Daejeon 34943, Korea.
Department of Internal Medicine, Korea University College of Medicine, Korea University Guro Hospital, Seoul 08308, Korea.
Int J Mol Sci. 2020 Sep 12;21(18):6686. doi: 10.3390/ijms21186686.
Sirtuins (SIRTs) are class III histone deacetylases (HDACs) that play important roles in aging and a wide range of cellular functions. Sirtuins are crucial to numerous biological processes, including proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammals have seven different sirtuins, SIRT1-7, and the diverse biological functions of each sirtuin are due to differences in subcellular localization, expression profiles, and cellular substrates. In this review, we summarize research advances into the role of sirtuins in the pathogenesis of various kidney diseases including acute kidney injury, diabetic kidney disease, renal fibrosis, and kidney aging along with the possible underlying molecular mechanisms. The available evidence indicates that sirtuins have great potential as novel therapeutic targets for the prevention and treatment of kidney diseases.
沉默调节蛋白（Sirtuins，SIRTs）是 III 类组蛋白去乙酰化酶（HDACs），在衰老和广泛的细胞功能中发挥重要作用。Sirtuins 对许多生物学过程至关重要，包括增殖、DNA 修复、线粒体能量稳态和抗氧化活性。哺乳动物有七种不同的 Sirtuins，即 SIRT1-7，每种 Sirtuins 的不同生物学功能归因于亚细胞定位、表达谱和细胞底物的差异。在这篇综述中，我们总结了 Sirtuins 在各种肾脏疾病发病机制中的作用的研究进展，包括急性肾损伤、糖尿病肾病、肾纤维化和肾脏衰老，以及潜在的分子机制。现有证据表明，Sirtuins 作为预防和治疗肾脏疾病的新型治疗靶点具有巨大潜力。
