Aprea Giuseppe, Scattolini Silvia, D'Angelantonio Daniela, Chiaverini Alexandra, Di Lollo Valeria, Olivieri Sabrina, Marcacci Maurilia, Mangone Iolanda, Salucci Stefania, Antoci Salvatore, Cammà Cesare, Di Pasquale Adriano, Migliorati Giacomo, Pomilio Francesco
Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise "G. Caporale", 64100 Teramo, Italy.
Local health unit "ASL Teramo", 64100 Teramo, Italy.
Microorganisms. 2020 Sep 11;8(9):1393. doi: 10.3390/microorganisms8091393.
Hepatitis E virus (HEV) is an emergent zoonotic pathogen, causing worldwide acute and chronic hepatitis in humans. HEV comprises eight genotypes and several subtypes. HEV genotypes 3 and 4 (HEV3 and HEV4) are zoonotic. In Italy, the most part of HEV infections (80%) is due to autochthonous HEV3 circulation of the virus, and the key role played by wild animals is generally accepted. Abruzzo is an Italian region officially considered an HEV "hot spot", with subtype HEV3- being up to now the only one reported among wild boars. During the year 2018-2019, a group of wild boars in Abruzzo were screened for HEV; positive RNA liver samples were subjected to HEV characterization by using the whole genome sequencing (WGS) approach methodology. This represents the first report about the detection of HEV-3 subtypes and in the wild boar population in this area. Since in Italy human infections from HEV 3- and have been associated with pork meat consumption, our findings deserve more in-depth analysis with the aim of evaluating any potential correlation between wild animals, the pork chain production and HEV human infections.
戊型肝炎病毒（HEV）是一种新出现的人畜共患病原体，可在全球范围内引发人类急性和慢性肝炎。HEV包括八个基因型和几个亚型。HEV基因型3和4（HEV3和HEV4）是人畜共患病型。在意大利，大部分HEV感染（80%）是由于该病毒在本地的HEV3传播，野生动物所起的关键作用已得到普遍认可。阿布鲁佐是意大利一个被官方认定为HEV“热点地区”的大区，到目前为止，HEV3-亚型是野猪中唯一报告的亚型。在2018 - 2019年期间，对阿布鲁佐的一群野猪进行了HEV筛查；对RNA呈阳性的肝脏样本采用全基因组测序（WGS）方法进行HEV特征分析。这是关于该地区野猪种群中检测到HEV-3亚型的首次报告。由于在意大利，人类感染HEV 3-和 与食用猪肉有关，我们的研究结果值得进行更深入的分析，以评估野生动物、猪肉产业链生产与人类HEV感染之间是否存在任何潜在关联。
