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聚对二甲苯涂层微针阵列电极的制作用于可穿戴心电图设备。

Fabrication of Parylene-Coated Microneedle Array Electrode for Wearable ECG Device.

机构信息

Department of Electronics Engineering, Gachon University, Seongnam-si, Gyeonggi-do 13210, Korea.

Gachon Advanced Institute for Health Science and Technology, Gachon University, Incheon 21999, Korea.

出版信息

Sensors (Basel). 2020 Sep 11;20(18):5183. doi: 10.3390/s20185183.

DOI:10.3390/s20185183
PMID:32932862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7570911/
Abstract

Microneedle array electrodes (MNE) showed immense potential for the sensitive monitoring of the bioelectric signals by penetrating the stratum corneum with high electrical impedance. In this paper, we introduce a rigid parylene coated microneedle electrode array and portable electrocardiography (ECG) circuit for monitoring of ECG reducing the motion artifacts. The developed MNE showed stability and durability for dynamic and long-term ECG monitoring in comparison to the typical silver-silver chloride (Ag/AgCl) wet electrodes. The microneedles showed no mechanical failure under the compression force up-to 16 N, but successful penetration of skin tissue with a low insertion force of 5 N. The electrical characteristics of the fabricated MNE were characterized by impedance spectroscopy with equivalent circuit model. The designed wearable wireless ECG monitoring device with MNE proved feasibility of the ECG recording which reduces the noise of movement artifacts during dynamic behaviors.

摘要

微针阵列电极(MNE)通过穿透高阻抗的角质层,显示出对生物电信号进行敏感监测的巨大潜力。在本文中,我们引入了一种刚性聚对二甲苯涂层的微针电极阵列和便携式心电图(ECG)电路,用于监测心电图,减少运动伪影。与典型的银-氯化银(Ag/AgCl)湿电极相比,所开发的 MNE 显示出在动态和长期 ECG 监测中的稳定性和耐用性。微针在高达 16 N 的压缩力下没有机械故障,但可以用低至 5 N 的插入力成功穿透皮肤组织。通过等效电路模型的阻抗谱对所制备的 MNE 的电特性进行了表征。带有 MNE 的设计的可穿戴无线 ECG 监测设备证明了 ECG 记录的可行性,可减少动态行为过程中运动伪影的噪声。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/3018a912e02e/sensors-20-05183-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/02ae07eb2d30/sensors-20-05183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/1b89f95c89c6/sensors-20-05183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/de2a313d94bb/sensors-20-05183-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/acaf81c1d854/sensors-20-05183-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/a068024dc82f/sensors-20-05183-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/b242c5e4c326/sensors-20-05183-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/ec8851854f5b/sensors-20-05183-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/7933e9884d6e/sensors-20-05183-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/ffd17304ce8e/sensors-20-05183-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/f32e183f7cf1/sensors-20-05183-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/3018a912e02e/sensors-20-05183-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/02ae07eb2d30/sensors-20-05183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/1b89f95c89c6/sensors-20-05183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/de2a313d94bb/sensors-20-05183-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/acaf81c1d854/sensors-20-05183-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/a068024dc82f/sensors-20-05183-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/b242c5e4c326/sensors-20-05183-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/ec8851854f5b/sensors-20-05183-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/7933e9884d6e/sensors-20-05183-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/ffd17304ce8e/sensors-20-05183-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/f32e183f7cf1/sensors-20-05183-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1489/7570911/3018a912e02e/sensors-20-05183-g012.jpg

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