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基于低熔点铋铟锡合金的用于心电图检测的金属微针阵列电极制造研究

A study on the fabrication of metal microneedle array electrodes for ECG detection based on low melting point Bi-In-Sn alloys.

作者信息

Gwak Hyunjong, Cho Sungbo, Song Yoon-Jae, Park Jung-Hwan, Seo Soonmin

机构信息

Department of BioNano Technology, Gachon University, Seongnam-Si, Gyeonggi-Do, 13120, Republic of Korea.

Department of Electronic Engineering, Gachon University, Seongnam-Si, Gyeonggi-Do, 13120, Republic of Korea.

出版信息

Sci Rep. 2023 Dec 21;13(1):22931. doi: 10.1038/s41598-023-50472-y.

Abstract

This study describes the fabrication and characteristics of microneedle array electrodes (MAEs) using Bismuth-Indium-Tin (Bi-In-Sn) alloys. The MAEs consist of 57 pyramid-shaped needles measuring 340 μm wide and 800 μm high. The fabrication process involved micromolding the alloys in a vacuum environment. Physical tests demonstrated that Bi-In-Sn MAEs have good mechanical strength, indicating their suitability for successful skin penetration. The electrode-skin interface impedance test confirmed that Bi-In-Sn MAEs successfully penetrated the skin. Impedance measurements revealed the importance of insulating the microneedle electrodes for optimal electrical performance, and a UV-curable Polyurethane Acrylate coating was applied to enhance insulation. Electrocardiogram measurements using the Bi-In-Sn MAEs demonstrated performance comparable to that of traditional Ag/AgCl electrodes, which shows promise for accurate data collection. Overall, the study demonstrates successful, minimally-invasive skin insertion, improved electrical insulation, and potential applications of Bi-In-Sn microneedle array. These findings contribute to advancements in microneedle technology for biomedical applications.

摘要

本研究描述了使用铋 - 铟 - 锡(Bi - In - Sn)合金制造微针阵列电极(MAE)及其特性。该微针阵列电极由57根金字塔形针组成,针宽340μm,高800μm。制造过程包括在真空环境中对合金进行微成型。物理测试表明,Bi - In - Sn微针阵列电极具有良好的机械强度,表明它们适合成功穿透皮肤。电极 - 皮肤界面阻抗测试证实Bi - In - Sn微针阵列电极成功穿透了皮肤。阻抗测量揭示了对微针电极进行绝缘以实现最佳电性能的重要性,并应用了紫外线固化聚氨酯丙烯酸酯涂层来增强绝缘。使用Bi - In - Sn微针阵列电极进行的心电图测量显示其性能与传统Ag/AgCl电极相当,这表明在准确数据采集方面具有前景。总体而言,该研究展示了Bi - In - Sn微针阵列成功实现微创皮肤插入、改善电绝缘以及潜在应用。这些发现有助于推动用于生物医学应用的微针技术的进步。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af38/10739879/843515fefdab/41598_2023_50472_Fig1_HTML.jpg

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