Bouchard C
Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Quebec, Canada.
Acta Med Scand Suppl. 1988;723:135-41. doi: 10.1111/j.0954-6820.1987.tb05936.x.
This paper reviews current data concerning the role of the genotype in human variation in fat distribution and its contribution in regulating fat deposition in various regions of the body, primarily the lower trunk area. After statistical control over age, gender and total amount of subcutaneous fat, one finds an additive genetic effect of about 20-25% of remaining human variance in amount of lower trunk fat and in the relative proportion of lower trunk versus extremity fat. In spite of such a moderate genetic effect in fat distribution, the preferential site of fat deposition when exposed to chronic overfeeding is largely determined by one's genotype. Characteristics of regional adipose tissue metabolism and morphology are probably involved in mediating some of these genetic effects but other regulatory mechanisms are undoubtedly implicated.
本文综述了有关基因型在人类脂肪分布变异中的作用及其对身体各部位（主要是下躯干区域）脂肪沉积调节作用的现有数据。在对年龄、性别和皮下脂肪总量进行统计控制后，人们发现，下躯干脂肪量以及下躯干与四肢脂肪相对比例中，约20%-25%的剩余人类变异存在加性遗传效应。尽管在脂肪分布方面存在这种中等程度的遗传效应，但长期过度喂养时脂肪沉积的优先部位在很大程度上由个体基因型决定。区域脂肪组织代谢和形态特征可能参与介导其中一些遗传效应，但无疑也涉及其他调节机制。
