Jin Yarong, Li Ruilei, Zhang Zhiwei, Ren Jinjin, Song Xin, Zhang Gong
Department of Radiotherapy, People's Hospital of Shanxi Province, Taiyuan, Shanxi 030012, P.R. China.
Department of Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan 650118, P.R. China.
Oncol Lett. 2020 Nov;20(5):137. doi: 10.3892/ol.2020.11997. Epub 2020 Aug 20.
Maintenance of genomic diversity is critically dependent on gene regulation at the transcriptional level. This occurs via the interaction of regulatory DNA sequence motifs with DNA-binding transcription factors. The zinc finger, BED-type (ZBED) gene family contains major DNA-binding motifs present in human transcriptional factors. It encodes proteins that present markedly diverse regulatory functions. ZBED1 has similar structural and functional properties to its homolog DNA replication-related element-binding factor (DREF) and plays a critical role in the regulation of transcription. ZBED1 regulates the expression of several genes associated with cell proliferation, including cell cycle regulation, chromatin remodeling and protein metabolism, and some genes associated with apoptosis and differentiation. In the present review, the origin, structure and functional role of ZBED1 were comprehensively assessed. In addition, the similarities and differences between ZBED1 and its homolog DREF were highlighted, and future research directions, particularly in the area of clinical cancer, were discussed.
基因组多样性的维持严重依赖于转录水平的基因调控。这是通过调控DNA序列基序与DNA结合转录因子的相互作用来实现的。锌指BED型（ZBED）基因家族包含人类转录因子中存在的主要DNA结合基序。它编码具有明显不同调控功能的蛋白质。ZBED1与其同源物DNA复制相关元件结合因子（DREF）具有相似的结构和功能特性，并在转录调控中起关键作用。ZBED1调节几个与细胞增殖相关的基因的表达，包括细胞周期调控、染色质重塑和蛋白质代谢，以及一些与凋亡和分化相关的基因。在本综述中，全面评估了ZBED1的起源、结构和功能作用。此外，还强调了ZBED1与其同源物DREF之间的异同，并讨论了未来的研究方向，特别是在临床癌症领域。
