Department of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Adv Mater. 2022 Feb;34(5):e2107177. doi: 10.1002/adma.202107177. Epub 2021 Dec 18.
There has been considerable interest in developing synthetic micromotors with biofunctional, versatile, and adaptive capabilities for biomedical applications. In this perspective, cell membrane-functionalized micromotors emerge as an attractive platform. This new class of micromotors demonstrates enhanced propulsion and compelling performance in complex biological environments, making them suitable for various in vivo applications, including drug delivery, detoxification, immune modulation, and phototherapy. This article reviews various proof-of-concept studies based on different micromotor designs and cell membrane coatings in these areas. The review focuses on the motor structure and performance relationship and highlights how cell membrane functionalization overcomes the obstacles faced by traditional synthetic micromotors while imparting them with unique capabilities. Overall, the cell membrane-functionalized micromotors are expected to advance micromotor research and facilitate its translation towards practical uses.
人们对于开发具有生物功能、多功能和自适应能力的合成微马达，以应用于生物医学领域，表现出浓厚的兴趣。在这方面，细胞膜功能化的微马达作为一种有吸引力的平台出现了。这一新类别的微马达在复杂的生物环境中表现出增强的推进力和引人注目的性能，使其适用于各种体内应用，包括药物输送、解毒、免疫调节和光疗。本文综述了基于不同微马达设计和细胞膜涂层的这些领域的各种概念验证研究。本文重点介绍了马达结构与性能的关系，并强调了细胞膜功能化如何克服传统合成微马达所面临的障碍，同时赋予它们独特的能力。总的来说，细胞膜功能化的微马达有望推动微马达研究，并促进其向实际应用的转化。
