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小胶质细胞在哺乳动物光感受器死亡过程中的激活和炎症反应。

Microglia Activation and Inflammation During the Death of Mammalian Photoreceptors.

机构信息

Department of Cell Biology and Human Anatomy, University of California, Davis, Davis, California 95616, USA; email:

Center for Neuroscience, University of California, Davis, Davis, California 95616, USA; email:

出版信息

Annu Rev Vis Sci. 2020 Sep 15;6:149-169. doi: 10.1146/annurev-vision-121219-081730.

DOI:10.1146/annurev-vision-121219-081730
PMID:32936734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10135402/
Abstract

Photoreceptors are highly specialized sensory neurons with unique metabolic and physiological requirements. These requirements are partially met by Müller glia and cells of the retinal pigment epithelium (RPE), which provide essential metabolites, phagocytose waste, and control the composition of the surrounding microenvironment. A third vital supporting cell type, the retinal microglia, can provide photoreceptors with neurotrophic support or exacerbate neuroinflammation and hasten neuronal cell death. Understanding the physiological requirements for photoreceptor homeostasis and the factors that drive microglia to best promote photoreceptor survival has important implications for the treatment and prevention of blinding degenerative diseases like retinitis pigmentosa and age-related macular degeneration.

摘要

感光细胞是具有独特代谢和生理需求的高度特化的感觉神经元。Müller 胶质细胞和视网膜色素上皮细胞（RPE）部分满足这些需求，它们提供必需的代谢物、吞噬废物，并控制周围微环境的组成。第三种重要的支持细胞类型是视网膜小胶质细胞，它可以为感光细胞提供神经营养支持，也可以加剧神经炎症并加速神经元细胞死亡。了解感光细胞动态平衡的生理需求以及促使小胶质细胞最佳促进感光细胞存活的因素，对于治疗和预防致盲退行性疾病如色素性视网膜炎和年龄相关性黄斑变性具有重要意义。

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[7]
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[10]
Photoreceptor loss does not recruit neutrophils despite strong microglial activation.

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本文引用的文献

[1]
Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program.

Cell. 2019-12-12

[2]
Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling.

Nat Neurosci. 2019-10-21

[3]
A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration.

Int J Mol Sci. 2019-9-27

[4]
Systemic knockout of Tspo in mice does not affect retinal morphology, function and susceptibility to degeneration.

Exp Eye Res. 2019-9-25

[5]
Systemic taurine treatment provides neuroprotection against retinal photoreceptor degeneration and visual function impairments.

Drug Des Devel Ther. 2019-8-7

[6]
Microglia in Retinal Degeneration.

Front Immunol. 2019-8-20

[7]
Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.

Nat Commun. 2019-8-21

[8]
Cellular mechanisms of hereditary photoreceptor degeneration - Focus on cGMP.

Prog Retin Eye Res. 2020-1

[9]
In vivo imaging reveals transient microglia recruitment and functional recovery of photoreceptor signaling after injury.

Proc Natl Acad Sci U S A. 2019-7-26

[10]
Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis.

Cell Death Dis. 2019-7-18

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