Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA; Yale Center for Research on Aging, Yale School of Medicine, New Haven, CT 06520, USA.
Immunity. 2020 Sep 15;53(3):510-523. doi: 10.1016/j.immuni.2020.08.013.
Integrated immunometabolic responses link dietary intake, energy utilization, and storage to immune regulation of tissue function and is therefore essential for the maintenance and restoration of homeostasis. Adipose-resident leukocytes have non-traditional immunological functions that regulate organismal metabolism by controlling insulin action, lipolysis, and mitochondrial respiration to control the usage of substrates for production of heat versus ATP. Energetically expensive vital functions such as immunological responses might have thus evolved to respond accordingly to dietary surplus and deficit of macronutrient intake. Here, we review the interaction of dietary intake of macronutrients and their metabolism with the immune system. We discuss immunometabolic checkpoints that promote healthspan and highlight how dietary fate and regulation of glucose, fat, and protein metabolism might affect immunity.
整合免疫代谢反应将饮食摄入、能量利用和储存与免疫调节组织功能联系起来，因此对于维持和恢复体内平衡至关重要。脂肪组织驻留的白细胞具有非传统的免疫功能，通过控制胰岛素作用、脂肪分解和线粒体呼吸来调节机体代谢，从而控制用于产生热量与 ATP 的底物的利用。因此，免疫等能量消耗大的重要功能可能已经进化到能够相应地对宏量营养素摄入的饮食过剩和不足做出反应。在这里，我们综述了饮食中宏量营养素的摄入及其代谢与免疫系统的相互作用。我们讨论了促进健康寿命的免疫代谢检查点，并强调了饮食命运和葡萄糖、脂肪和蛋白质代谢的调节如何影响免疫。
