Coldbeck-Shackley Rosa C, Eyre Nicholas S, Beard Michael R
School of Biological Sciences, Research Centre for Infectious Diseases, The University of Adelaide, Adelaide, SA 5005, Australia.
College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Vaccines (Basel). 2020 Sep 14;8(3):530. doi: 10.3390/vaccines8030530.
Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the genus that cause significant disease in humans. Existing control measures have been ineffective at curbing the increasing global incidence of infection for both viruses and they are therefore prime targets for new vaccination strategies. Type-I interferon (IFN) responses are important in clearing viral infection and for generating efficient adaptive immune responses towards infection and vaccination. However, ZIKV and DENV have evolved multiple molecular mechanisms to evade type-I IFN production. This review covers the molecular interactions, from detection to evasion, of these viruses with the type-I IFN response. Additionally, we discuss how this knowledge can be exploited to improve the design of new vaccine strategies.
寨卡病毒（ZIKV）和登革病毒（DENV）是该属中相关的病毒，可在人类中引发严重疾病。现有的控制措施在抑制这两种病毒在全球不断上升的感染发病率方面均未见成效，因此它们是新疫苗策略的主要目标。I型干扰素（IFN）反应在清除病毒感染以及对感染和疫苗接种产生有效的适应性免疫反应方面很重要。然而，寨卡病毒和登革病毒已经进化出多种分子机制来逃避I型干扰素的产生。本综述涵盖了这些病毒与I型干扰素反应从检测到逃避的分子相互作用。此外，我们还讨论了如何利用这些知识来改进新疫苗策略的设计。
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