Samaranayake L P, Robertson A G, MacFarlane T W, Hunter I P, MacFarlane G, Soutar D S, Ferguson M M
Department of Oral Medicine & Pathology, Glasgow Dental Hospital & School, Scotland.
Clin Radiol. 1988 May;39(3):291-4. doi: 10.1016/s0009-9260(88)80538-5.
A variety of mouthwashes are frequently used in the management of irradiation-induced mucositis. Benzydamine has recently been introduced for alleviating this condition. Its efficacy as a mouthwash was compared with chlorhexidine in two groups of patients receiving radiotherapy for oral carcinoma. Mucositis and pain were recorded over a 6 week period and oral carriage of Candida species, coliforms and Staphylococcus aureus was assessed using an oral rinse technique. There was no significant difference in the mucositis scores, overall pain scores or the yeast and bacterial species isolated between the two treatment groups. However, 58% (7 out of 12) and 92% (12 out of 13) patients reported oral discomfort when rinsing the mouth with chlorhexidine and benzydamine, respectively. In both groups, the most common coliform isolated was Klebsiella pneumoniae and the carriage of yeasts was significantly greater than that of coliforms. These results indicate that, although the individual patient acceptance of chlorhexidine is better than benzydamine, there is little difference between the two mouthwashes both in controlling pain and mucositis or in the oral carriage of the micro-organisms studied.
多种漱口水常用于放射性口腔黏膜炎的治疗。近来引入了苄达明用于缓解这种病症。在两组接受口腔癌放疗的患者中，比较了苄达明漱口水与氯己定漱口水的疗效。在6周期间记录口腔黏膜炎和疼痛情况，并使用口腔冲洗技术评估念珠菌属、大肠菌群和金黄色葡萄球菌的口腔携带情况。两个治疗组之间在口腔黏膜炎评分、总体疼痛评分或分离出的酵母和细菌种类方面没有显著差异。然而，分别有58%（12例中的7例）和92%（13例中的12例）的患者在用氯己定和苄达明漱口时报告有口腔不适。在两组中，分离出的最常见大肠菌群是肺炎克雷伯菌，酵母的携带率明显高于大肠菌群。这些结果表明，尽管氯己定在患者个体接受度上优于苄达明，但在控制疼痛和口腔黏膜炎或在所研究微生物的口腔携带方面，两种漱口水之间几乎没有差异。
