Department of Pharmaceutical Technology, Eberhard Karls University, Auf der Morgenstelle 8, 72076 Tuebingen, Germany.
Molecules. 2020 Sep 15;25(18):4222. doi: 10.3390/molecules25184222.
In the development of dermal drug formulations and cosmetics, understanding the penetration properties of the active ingredients is crucial. Given that widespread methods, including tape stripping, lack in spatial resolution, while being time- and labour-intensive, Confocal Raman Microscopy is a promising alternative. In optimizing topically applied formulations, or the development of generic formulations, comparative in-situ measurements have a huge potential of saving time and resources. In this work, we show our approach to in-situ skin penetration analysis by confocal Raman Microscopy. To analyse feasibility of the approach, we used caffeine solutions as model vehicles and tested the effectiveness of 1,2-pentanediol as a penetration enhancer for delivery to the skin.
在皮肤药物制剂和化妆品的开发中，了解活性成分的渗透特性至关重要。鉴于包括胶带剥离在内的广泛方法在空间分辨率方面存在不足，同时还费时费力，共聚焦拉曼显微镜是一种很有前途的替代方法。在优化局部应用制剂或开发通用制剂方面，原位比较测量具有节省时间和资源的巨大潜力。在这项工作中，我们展示了我们通过共聚焦拉曼显微镜进行原位皮肤渗透分析的方法。为了分析该方法的可行性，我们使用咖啡因溶液作为模型载体，并测试了 1,2-戊二醇作为渗透增强剂用于递送至皮肤的效果。
