Department of Biochemistry, Yogi Vemana Universiti, Vemanapuram, Kadapa-516005, A.P, India.
West High School, Torrance- 90503, CA 90503, United States.
Curr Pharm Des. 2021;27(6):802-815. doi: 10.2174/1381612826999200917154747.
Phytoestrogens are non-endocrine, non-steroidal secondary derivatives of plants and consumed through a plant-based diet also named as "dietary estrogens". The major sources of phytoestrogens are soy and soy-based foods, flaxseed, chickpeas, green beans, dairy products, etc. The dietary inclusion of phytoestrogen based foods plays a crucial role in the maintenance of metabolic syndrome cluster, including obesity, diabetes, blood pressure, cancer, inflammation, cardiovascular diseases, postmenopausal ailments and their complications. In recent days, phytoestrogens are the preferred molecules for hormone replacement therapy. On the other hand, they act as endocrine disruptors via estrogen receptor-mediated pathways. These effects are not restricted to adult males or females and identified even in development.
Since phytoestrogenic occurrence is high at daily meals for most people worldwide, they focused to study for its beneficiary effects towards developing pharmaceutical drugs for treating various metabolic disorders by observing endocrine disruption.
The present review emphasizes the pros and cons of phytoestrogens on human health, which may help to direct the pharmaceutical industry to produce various phytoestrongen based drugs against various metabolic disorders.
植物雌激素是植物的非内分泌、非甾体类次级衍生物，通过植物性饮食（也称为“饮食雌激素”）摄入。植物雌激素的主要来源是大豆和大豆制品、亚麻籽、鹰嘴豆、绿豆、乳制品等。饮食中包含植物雌激素类食物对维持代谢综合征群（包括肥胖、糖尿病、血压、癌症、炎症、心血管疾病、绝经后疾病及其并发症）起着至关重要的作用。最近，植物雌激素已成为激素替代疗法的首选分子。另一方面，它们通过雌激素受体介导的途径充当内分泌干扰物。这些影响不仅限于成年男性或女性，甚至在发育过程中也有发现。
由于植物雌激素在世界上大多数人的日常饮食中含量很高，因此人们专注于研究其有益作用，通过观察内分泌干扰来开发治疗各种代谢紊乱的药物。
本综述强调了植物雌激素对人类健康的利弊，这可能有助于指导制药行业生产各种基于植物雌激素的药物来治疗各种代谢紊乱。
