Narayanan Divya, Wallstrom Garrick, Rodriguez John, Welch Donna, Chapin Matthew, Arrigg Paul, Patil Rajkumar, Abelson Mark
Ora, Inc, Andover, MA, USA.
Statistics and Data Corporation, Tempe, AZ, USA.
Clin Ophthalmol. 2020 Sep 3;14:2571-2576. doi: 10.2147/OPTH.S260787. eCollection 2020.
Early detection and treatment of age-related macular degeneration require a clear understanding of the early progress of the disease. The purpose of this study was to investigate whether minimal macular ophthalmoscopic changes corresponded to changes in visual function.
Color macular photos from a group of older subjects who were classified as grade 0 on AREDS simplified grading were further evaluated by a retinal specialist using 5x magnification for possible minimal macular anomalies. Group 0-A ( = 15) were defined as subjects with no visible macular anomalies while Group 0-B ( = 19) comprised subjects for whom minimal macular mottling, pigment changes or very small drusen (< 63 µm) were observed in the study eye. All subjects had best VA of 20/25 or better and had no evidence of other retinal diseases in the study eye. All subjects underwent a series of visual function tests such as standard ETDRS VA, low luminance ETDRS VA, Pelli-Robson contrast sensitivity, variable contrast flicker (VCF) sensitivity, and reading speed (words per minute, wpm) using both MNRead and low luminance reading on a tablet.
There was no significant difference between the mean age between the two groups (74.8 ± 5.2 years for 0-A vs 74.5 ± 4.4 for 0-B, = 0.82). None of the visual function tests identified any significant difference between the two groups. Mean ETDRS VA was 0.0 ± 0.11 for 0-A subjects and 0.08 ± 0.12 for 0-B ( = 0.063). Mean Pelli-Robson log contrast sensitivity was 1.75 ± 0.29 for 0-A and 1.78 ± 0.17 for the 0-B group ( = 0.73). VCF threshold was 0.47 ± 0.25 for 0-A and 0.43 ± 0.22 for 0-B ( = 0.64). Reading speed using MNRead was 214 ± 47.4 wpm for 0-A and 210 ± 64.7 for 0-B ( = 0.85). Low luminance tablet reading speed was 137 ± 71.8 wpm for 0-A and 151 ± 39.4 (0-B) ( = 0.49).
A panel of psychophysical tests did not demonstrate significant differences between subjects with and without minimal macular changes.
年龄相关性黄斑变性的早期检测和治疗需要清楚了解该疾病的早期进展情况。本研究的目的是调查黄斑部检眼镜下的微小变化是否与视觉功能的变化相对应。
一组在年龄相关性眼病研究（AREDS）简化分级中被归类为0级的老年受试者的彩色黄斑照片，由视网膜专科医生使用5倍放大倍数进一步评估，以查找可能存在的微小黄斑异常。0 - A组（n = 15）被定义为黄斑部无可见异常的受试者，而0 - B组（n = 19）包括在研究眼中观察到有微小黄斑斑纹、色素变化或非常小的玻璃膜疣（< 63 µm）的受试者。所有受试者的最佳视力均为20/25或更好，且研究眼中无其他视网膜疾病的证据。所有受试者都接受了一系列视觉功能测试，如标准早期糖尿病性视网膜病变研究（ETDRS）视力、低亮度ETDRS视力、佩利 - 罗布森对比敏感度、可变对比闪烁（VCF）敏感度，以及在平板电脑上使用MNRead和低亮度阅读的阅读速度（每分钟字数，wpm）。
两组之间的平均年龄无显著差异（0 - A组为74.8 ± 5.2岁，0 - B组为74.5 ± 4.4岁，P = 0.82）。没有一项视觉功能测试能识别出两组之间的任何显著差异。0 - A组受试者的平均ETDRS视力为0.0 ± 0.11，0 - B组为0.08 ± 0.12（P = 0.063）。0 - A组的平均佩利 - 罗布森对数对比敏感度为1.75 ± 0.29，0 - B组为1.78 ± 0.17（P = 0.73）。VCF阈值在0 - A组为0.47 ± 0.25，在0 - B组为0.43 ± 0.22（P = 0.64）。使用MNRead的阅读速度在0 - A组为214 ± 47.4 wpm，在0 - B组为210 ± 64.7（P = 0.85）。平板电脑低亮度阅读速度在0 - A组为137 ± 71.8 wpm，在0 - B组为151 ± 39.4（P = 0.49）。
一组心理物理学测试未显示有微小黄斑变化和无微小黄斑变化的受试者之间存在显著差异。
