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长链非编码RNA SNHG15通过靶向miR141/PD-L1促进胃癌的免疫逃逸。

LncRNA SNHG15 Contributes to Immuno-Escape of Gastric Cancer Through Targeting miR141/PD-L1.

作者信息

Dang Shengchun, Malik Abdul, Chen Jixiang, Qu Jianguo, Yin Kai, Cui Lei, Gu Min

机构信息

Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province 212001, People's Republic of China.

Department of General Surgery, Pucheng Hospital, Weinan, Shaanxi Province 715500, People's Republic of China.

出版信息

Onco Targets Ther. 2020 Aug 24;13:8547-8556. doi: 10.2147/OTT.S251625. eCollection 2020.

DOI:10.2147/OTT.S251625
PMID:32943878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7468375/
Abstract

INTRODUCTION

Long non-coding RNAs (lncRNAs) have been demonstrated to participate in many biological processes and severs as important regulators during the progression of gastric cancer.

METHODS

Here, we introduced human lncRNA SNHG15 which was highly expressed in gastric cancer and cells. Interestingly, the expression of SNHG15 was correlated with programmed cell death ligand 1 (PD-L1), which promotes the resistance of gastric cancer cells to immune responses. Meanwhile, SNHG15 downregulation suppressed the expression of PD-L1 and resistance of immune responses.

RESULTS

Further, our results suggested that SNHG15 acted as a competing endogenous RNA (CeRNA) to sponge miR-141, which was downregulated in gastric cancers and negatively correlated to PD-L1.

CONCLUSION

Our results suggested that SNHG15 improved the expression of PD-L1 by inhibiting miR-141, which in turn promoted the resistance of stomach cancer cells to the immune responses.

摘要

引言

长链非编码RNA（lncRNAs）已被证明参与许多生物学过程，并在胃癌进展过程中作为重要的调节因子。

方法

在此，我们引入了在胃癌和细胞中高表达的人lncRNA SNHG15。有趣的是，SNHG15的表达与程序性细胞死亡配体1（PD-L1）相关，PD-L1可促进胃癌细胞对免疫反应的抗性。同时，SNHG15的下调抑制了PD-L1的表达和免疫反应抗性。

结果

此外，我们的结果表明，SNHG15作为竞争性内源性RNA（CeRNA）来吸附miR-141，miR-141在胃癌中表达下调且与PD-L在1呈负相关。

结论

我们的结果表明，SNHG15通过抑制miR-141来提高PD-L1的表达，这反过来又促进了胃癌细胞对免疫反应的抗性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/87832c4672e4/OTT-13-8547-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/6ac4d0632282/OTT-13-8547-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/631ca3a60218/OTT-13-8547-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/d222c4396079/OTT-13-8547-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/039771be095e/OTT-13-8547-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/c27e23294e01/OTT-13-8547-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/391345b3139b/OTT-13-8547-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/87832c4672e4/OTT-13-8547-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/6ac4d0632282/OTT-13-8547-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/631ca3a60218/OTT-13-8547-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/d222c4396079/OTT-13-8547-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/039771be095e/OTT-13-8547-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/c27e23294e01/OTT-13-8547-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/391345b3139b/OTT-13-8547-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fccc/7468375/87832c4672e4/OTT-13-8547-g0007.jpg

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