Silva Jéssica Manoelli Costa, Teixeira Eliel Barbosa, Mourão Ronald Matheus da Silva, Ferraz Rafaella Sousa, Moreira Fabiano Cordeiro, de Assumpção Paulo Pimentel, Calcagno Danielle Queiroz
Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belem, Pará, Brazil.
Laboratório de Genética Humana e Médica, Universidade Federal do Pará, Belem, Pará, Brazil.
Front Pharmacol. 2023 Aug 21;14:1237723. doi: 10.3389/fphar.2023.1237723. eCollection 2023.
Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.
胃癌（GC）是一种在全球范围内高度流行且致命的恶性肿瘤。目前，长链非编码RNA（lncRNAs）最近已被确定为参与胃癌发生和发展的关键调节因子。lncRNAs的表达失调通常与肿瘤迁移、侵袭性增强以及治疗耐药性相关，这凸显了它们作为临床应用中有前景的靶点的潜力。这篇综述全面回顾了lncRNAs在胃癌中的研究历程，描述了其分子机制，并讨论了将lncRNAs确立为精准生物标志物的前景和挑战。
