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骨髓基质抗原2是高级别胶质瘤潜在的不良预后因素。

Bone Marrow Stromal Antigen 2 is a Potential Unfavorable Prognostic Factor for High-Grade Glioma.

作者信息

Shi Haiping, Luo Ke, Huang Wei

机构信息

Department of Neurosurgery, Suining Central Hospital, Suining, Sichuan, People's Republic of China.

出版信息

Onco Targets Ther. 2020 Aug 26;13:8723-8734. doi: 10.2147/OTT.S258631. eCollection 2020.

DOI:10.2147/OTT.S258631
PMID:32943880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7468947/
Abstract

BACKGROUND

Bone marrow stromal antigen 2 (BST2) is considered as a transmembrane glycoprotein and plays essential roles in innate immunity. It has been recently reported that up-regulation of BST2 was associated with the development of breast carcinoma. However, the clinical significance of BST2 in glioma has not been identified. The purpose of the present study is to explore the expression pattern and the role of BST2 in the progression of high-grade glioma.

METHODS

Expression levels of BST2 were tested in glioma tissues by analyzing the GEO database and immunohistochemistry staining. The prognostic role of BST2 in glioma was evaluated through univariate and multivariate analyses. In vitro and in vivo assays were conducted to confirm the role of BST2 on promoting glioma proliferation.

RESULTS

The mRNA level of BST2 was higher in glioma tissues than that in nontumorous brain tissues. High protein level of BST2 was correlated with larger tumor size and advanced WHO grade. Glioma patients with a high BST2 level had worse overall survival. In addition, BST2 was defined as an independent risk factor for glioma prognosis. Cellular and xenograft studies revealed that BST2 can significantly promote glioma proliferation.

CONCLUSION

Our study revealed that a high BST2 expression level was closely related to the unfavorable clinical features and poor prognosis of high-grade glioma patients. BST2 may serve as an invaluable prognostic indicator and novel therapeutic target for glioma treatment considering its membrane localization.

摘要

背景

骨髓基质抗原2（BST2）被认为是一种跨膜糖蛋白，在先天免疫中发挥重要作用。最近有报道称，BST2的上调与乳腺癌的发生发展有关。然而，BST2在胶质瘤中的临床意义尚未明确。本研究的目的是探讨BST2在高级别胶质瘤进展中的表达模式及作用。

方法

通过分析GEO数据库和免疫组织化学染色检测胶质瘤组织中BST2的表达水平。通过单因素和多因素分析评估BST2在胶质瘤中的预后作用。进行体外和体内实验以证实BST2对促进胶质瘤增殖的作用。

结果

胶质瘤组织中BST2的mRNA水平高于非肿瘤脑组织。BST2蛋白水平高与肿瘤体积大及世界卫生组织（WHO）分级高相关。BST2水平高的胶质瘤患者总生存期较差。此外，BST2被确定为胶质瘤预后的独立危险因素。细胞和异种移植研究表明，BST2可显著促进胶质瘤增殖。

结论

我们的研究表明，BST2高表达水平与高级别胶质瘤患者不良的临床特征和预后密切相关。鉴于其膜定位，BST2可能作为一种有价值的预后指标和胶质瘤治疗的新靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26eb/7468947/e699b3636dd2/OTT-13-8723-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26eb/7468947/bb8fa9f14e1a/OTT-13-8723-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26eb/7468947/f07880a518e1/OTT-13-8723-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26eb/7468947/a0da71bbcd23/OTT-13-8723-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26eb/7468947/e699b3636dd2/OTT-13-8723-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26eb/7468947/bb8fa9f14e1a/OTT-13-8723-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26eb/7468947/f07880a518e1/OTT-13-8723-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26eb/7468947/a0da71bbcd23/OTT-13-8723-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26eb/7468947/e699b3636dd2/OTT-13-8723-g0004.jpg

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