Norchai Phawit, Tharavanij Thipaporn, Suwannahitatorn Picha, Charernboon Thammanard
Department of Clinical Epidemiology, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Endocrinology and Metabolism Unit, Department of Medicine, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Med Devices (Auckl). 2020 Sep 3;13:237-243. doi: 10.2147/MDER.S268948. eCollection 2020.
Metabolic syndrome is diagnosed using clinical and laboratory data. Electro interstitial scan (EIS) is a rapid and noninvasive screening. It measures and calculates the parameters to reflect hypertension, sympathetic activity, stiffness of the arteries, body fat composition, leptin and insulin resistance. Metabolic syndrome will be diagnosed if calculated score ≥10 CU.
To evaluate the accuracy, validity and appropriate cut-off score to diagnose metabolic syndrome.
A cross-sectional study was conducted using the population-based approach. Metabolic syndrome was diagnosed according to the modified National Cholesterol Education Program (NCEP ATP III) and International Diabetes Federation (IDF) criteria. The appropriate cut-off score to diagnose metabolic syndrome by instrument was determined.
A total of 253 participants were enrolled with mean age of 40.06±6.33 years, and 64.43% (163/253) were female. Metabolic syndrome was diagnosed among 123 (48.62%) and 104 (41.11%) patients according to the NCEP ATP III and IDF criteria, respectively. The diagnostic indices of metabolic syndrome score ≥10 CU had a sensitivity of 23.6% and 27.9%, a specificity of 100% and area under ROC of 0.62 and 0.64, according to the NCEP ATP III and IDF criteria, respectively. The best cut-off level of metabolic syndrome score was ≥9 CU with a sensitivity of 79.67% (95% CI, 71.5-86.4%) and 88.46% (95% CI, 80.7-93.9%), a specificity of 96.92% (95% CI, 92.3-99.2%) and 93.29% (95% CI, 88.0-96.7%) and area under ROC 0.89 (95% CI, 0.85-0.93) and 0.92 (95% CI, 0.88-0.95), respectively, according to the NCEP ATP III and IDF criteria.
Screening of metabolic syndrome using ES TECK in a Thai population demonstrated inadequate accuracy when using metabolic syndrome score ≥10 CU. We recommend using a metabolic syndrome score ≥9 CU to provide the best accuracy. This instrument is safe, fast and easy to use for metabolic syndrome screening.
代谢综合征通过临床和实验室数据进行诊断。电间质扫描（EIS）是一种快速且无创的筛查方法。它测量并计算反映高血压、交感神经活动、动脉僵硬度、身体脂肪成分、瘦素和胰岛素抵抗的参数。如果计算得分≥10 CU，则诊断为代谢综合征。
评估诊断代谢综合征的准确性、有效性和合适的截断分数。
采用基于人群的方法进行横断面研究。根据改良的美国国家胆固醇教育计划（NCEP ATP III）和国际糖尿病联盟（IDF）标准诊断代谢综合征。确定通过该仪器诊断代谢综合征的合适截断分数。
共纳入253名参与者，平均年龄为40.06±6.33岁，女性占64.43%（163/253）。根据NCEP ATP III和IDF标准，分别有123名（48.62%）和部分内容缺失（此处原文有误，应是104名，41.11%）患者被诊断为代谢综合征。根据NCEP ATP III和IDF标准，代谢综合征得分≥10 CU的诊断指标的敏感性分别为23.6%和27.9%，特异性为100%，ROC曲线下面积分别为0.62和0.64。代谢综合征得分的最佳截断水平为≥9 CU，根据NCEP ATP III和IDF标准，敏感性分别为79.67%（95%CI，71.5 - 86.4%）和88.46%（95%CI，80.7 - 93.9%），特异性分别为96.92%（95%CI，92.3 - 99.2%）和93.29%（95%CI，88.0 - 96.7%），ROC曲线下面积分别为0.89（95%CI，0.85 - 0.93）和0.92（95%CI，0.88 - 0.95）。
在泰国人群中使用ES TECK筛查代谢综合征时，使用代谢综合征得分≥10 CU的准确性不足。我们建议使用代谢综合征得分≥9 CU以获得最佳准确性。该仪器用于代谢综合征筛查安全、快速且易于使用。
