Zacarías-Flores Mariano, Sánchez-Rodríguez Martha A, García-Anaya Oswaldo Daniel, Correa-Muñoz Elsa, Mendoza-Núñez Víctor Manuel
División de Ginecología y Obstetricia, Hospital Gustavo Baz Prada, Instituto de Salud del Estado de México, Nezahualcóyotl, Estado de México, México.
Unidad de Investigación en Gerontología, Facultad de Estudios Superiores Zaragoza, UNAM, Ciudad de México, México.
Endocrinol Diabetes Nutr (Engl Ed). 2018 Jun-Jul;65(6):328-334. doi: 10.1016/j.endinu.2018.01.009. Epub 2018 Apr 9.
Endocrine changes due to menopause have been associated to oxidative stress and muscle mass loss. The study objective was to determine the relationship between both variables in early postmenopause.
An exploratory, cross-sectional study was conducted in 107 pre- and postmenopausal women (aged 40-57 years). Levels of serum lipid peroxides and uric acid and enzymes superoxide dismutase and glutathione peroxidase, as well as total plasma antioxidant capacity were measured as oxidative stress markers. Muscle mass using bioelectrical impedance and muscle strength using dynamometry were also measured. Muscle mass, skeletal muscle index, fat-free mass, and body mass index were calculated.
More than 90% of participants were diagnosed with overweight or obesity. Postmenopausal women had lower values of muscle mass and strength markers, with a negative correlation between lipid peroxide level and skeletal muscle index (r= -0.326, p<.05), and a positive correlation between uric acid and skeletal muscle index (r=0.295, p<.05). A multivariate model including oxidative stress markers, age, and waist circumference showed lipid peroxide level to be the main contributor to explain the decrease in skeletal muscle mass in postmenopause, since for every 0.1μmol/l increase in lipid peroxide level, skeletal muscle index decreases by 3.03 units.
Our findings suggest an association between increased oxidative stress and muscle mass loss in early postmenopause.
绝经引起的内分泌变化与氧化应激和肌肉量减少有关。本研究的目的是确定绝经后早期这两个变量之间的关系。
对107名绝经前和绝经后女性（年龄40 - 57岁）进行了一项探索性横断面研究。测量血清脂质过氧化物、尿酸水平以及超氧化物歧化酶和谷胱甘肽过氧化物酶等酶，以及血浆总抗氧化能力作为氧化应激标志物。还使用生物电阻抗测量肌肉量，使用测力计测量肌肉力量。计算肌肉量、骨骼肌指数、去脂体重和体重指数。
超过90%的参与者被诊断为超重或肥胖。绝经后女性的肌肉量和力量标志物值较低，脂质过氧化物水平与骨骼肌指数呈负相关（r = -0.326，p <.05），尿酸与骨骼肌指数呈正相关（r = 0.295，p <.05）。一个包含氧化应激标志物、年龄和腰围的多变量模型显示，脂质过氧化物水平是解释绝经后骨骼肌量减少的主要因素，因为脂质过氧化物水平每增加0.1μmol/l，骨骼肌指数就会降低3.03个单位。
我们的研究结果表明，绝经后早期氧化应激增加与肌肉量减少之间存在关联。
