Department of Gerontology, 67828Federal University of São Carlos, São Carlos, SP, Brazil.
Engineering, Modelling and Applied Social Sciences Center (CECS), 488580Federal University of the ABC (UFABC), Santo André, SP, Brazil.
Clin EEG Neurosci. 2021 May;52(3):193-200. doi: 10.1177/1550059420959966. Epub 2020 Sep 18.
Apolipoprotein ε4 allele () is the strongest genetic risk factor for Alzheimer's disease and seems to be related to cognitive decline and damaged event-related potential P300, which is a sensitive measure to assess cognitive processing.
This research aims to critically review the existing scientific evidence regarding the association between and P300.
A systematic review was carried out up to January 2020 on the following databases: Web of Science, Scopus and Medline/PubMed. Articles were considered for inclusion if they are original research that provided information regarding the association between and P300, available in English, Spanish, or Portuguese, and available in full text. The methodological quality of the studies selected was evaluated using the quality assessment tool for observational cohort and cross-sectional studies recommended by Cochrane.
Out of 993 studies, 14 met the inclusion criteria. The results obtained showed that is related to a longer P300 latency. However, the data supplied do not allow us to confirm if this relationship also occurs in amplitude measures. Moreover, it was observed that genotype may influence P300 in different ages, from younger individuals to demented older people.
Evidence shows that negatively influences cortical activities related to cognitive functions, as indicated by P300.
载脂蛋白 E4 等位基因 () 是阿尔茨海默病最强的遗传风险因素，似乎与认知能力下降和受损的事件相关电位 P300 有关，P300 是评估认知处理能力的敏感指标。
本研究旨在批判性地回顾现有关于与 P300 之间关联的科学证据。
截至 2020 年 1 月，我们在以下数据库中进行了系统评价：Web of Science、Scopus 和 Medline/PubMed。如果符合以下标准，文章将被纳入考虑范围：原始研究，提供了关于与 P300 之间关联的信息，以英文、西班牙文或葡萄牙文发表，且全文可用。使用 Cochrane 推荐的观察性队列研究和横断面研究质量评估工具评估了所选研究的方法学质量。
在 993 项研究中，有 14 项符合纳入标准。研究结果表明，与 P300 潜伏期延长有关。然而，提供的数据并不能证实这种关系是否也存在于幅度测量中。此外，还观察到基因型可能会影响不同年龄的 P300，从年轻个体到痴呆老年人。
有证据表明，载脂蛋白 E4 等位基因对与认知功能相关的皮质活动有负面影响，这一点可以通过 P300 反映出来。
