Encephalopathy Center, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China.
Department of Orthopedics, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China.
Environ Toxicol. 2021 Feb;36(2):249-256. doi: 10.1002/tox.23030. Epub 2020 Sep 18.
Cardiovascular-related diseases continue to be a leading cause of death globally. Among ischemic-induced cardiac diseases, myocardial infarction (MI) is reported to be of an alarming value. Despite numerous improvements in the medical intrusions, still this armamentarium fails to be effective in managing the illness without setbacks. Ferruginol (FGL) is a major polyphenols and terpenoids with numerous pharmacological activities including antioxidant and anti-inflammatory. Following, this work was aimed to explore the cardio protective effect of FGL (50 mg/kg) in isoprenaline hydrochloride (ISO)-induced MI in experimental rats. After treatment with FGL in ISO-induced MI in rats, noticeable changes were observed in the experimental rats. Injection of ISO to rats resulted in the augmented cardiac weight, serum cardiac markers (creatine kinase, creatine kinase-MB, cardiac troponin T, and Cardiac troponin I), lipid peroxidation end products (thiobarbituric acid-reactive substance and lipid hydroperoxides), reduced endogenous antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione), reduced ATPase activity, and escalated pro-inflammatory cytokines (interleukin-6, tumor necrosis factor-α, and nuclear factor-κB) levels. Interestingly, the FGL supplementation to the ISO-treated rats revealed the diminished heart weight, reduced cardiac markers, and lipid peroxidation. FGL also possessed the improved antioxidants status and diminished pro-inflammatory mediator levels. The outcomes of histological analysis also evidenced the cardio protective role of FGL. Treatment with FGL reduced the cardiac damage biomarkers maintained to near normal levels in ISO-induced rats. These study findings disclose the prospective capability of FGL in the treatment of MI in the future.
心血管相关疾病仍然是全球主要的死亡原因。在缺血性心脏病中，心肌梗死（MI）的发病率令人震惊。尽管医学介入有了许多改进，但在没有挫折的情况下，这种方法仍然无法有效地治疗这种疾病。鞣花酸（FGL）是一种主要的多酚和萜类化合物，具有许多药理活性，包括抗氧化和抗炎作用。随后，这项工作旨在探讨 FGL（50mg/kg）在盐酸异丙肾上腺素（ISO）诱导的实验大鼠 MI 中的心脏保护作用。在 ISO 诱导的 MI 大鼠中用 FGL 治疗后，实验大鼠观察到明显的变化。向大鼠注射 ISO 会导致心肌重量增加，血清心脏标志物（肌酸激酶、肌酸激酶-MB、心肌肌钙蛋白 T 和心肌肌钙蛋白 I）、脂质过氧化终产物（硫代巴比妥酸反应物质和脂质过氧化物）、内源性抗氧化剂减少（超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和谷胱甘肽）、ATP 酶活性降低以及促炎细胞因子（白细胞介素 6、肿瘤坏死因子-α和核因子-κB）水平升高。有趣的是，FGL 补充到 ISO 处理的大鼠中，发现心脏重量减轻，心脏标志物减少，脂质过氧化减少。FGL 还具有改善的抗氧化状态和减少的促炎介质水平。组织学分析的结果也证明了 FGL 的心脏保护作用。用 FGL 治疗可降低 ISO 诱导大鼠心脏损伤生物标志物，使其维持在接近正常水平。这些研究结果揭示了 FGL 在未来治疗 MI 的潜在能力。
