Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Experiment Centre of Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China.
Trends Pharmacol Sci. 2020 Oct;41(10):701-714. doi: 10.1016/j.tips.2020.08.003.
The tumor microenvironment (TME) is a highly complex environment that surrounds tumors. Interactions between cancer cells/non-cancerous cells and cells/non-cell components in the TME support tumor initiation, development, and metastasis. Of the cell types in the TME, tumor-associated macrophages (TAMs) have gained attention owing to their crucial roles in supporting tumors and conferring therapy resistance. Recent developments in nanotechnology raise opportunities for the application of nano targeted drug-delivery systems (Nano-TDDS) in cancer therapy. We focus our discussion on current knowledge of TAMs, and describe recent examples of Nano-TDDS-based TAM modulation, highlighting strategies to overcome in vivo delivery barriers associated with the TME and their potential for clinical translation.
肿瘤微环境（TME）是包围肿瘤的高度复杂环境。肿瘤细胞/非肿瘤细胞与 TME 中的细胞/非细胞成分之间的相互作用支持肿瘤的起始、发展和转移。在 TME 中的细胞类型中，肿瘤相关巨噬细胞（TAMs）由于其在支持肿瘤和赋予治疗耐药性方面的关键作用而受到关注。纳米技术的最新发展为纳米靶向药物传递系统（Nano-TDDS）在癌症治疗中的应用提供了机会。我们专注于讨论当前关于 TAMs 的知识，并描述基于 Nano-TDDS 的 TAM 调节的最新实例，重点介绍克服与 TME 相关的体内递药障碍的策略及其临床转化的潜力。
