间歇性禁食饮食对炎症生物标志物血浆浓度的影响：随机对照试验的系统评价和荟萃分析。

Effects of intermittent fasting diets on plasma concentrations of inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials.

机构信息

Department of Endocrinology, Zhijiang Branch, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, 310000, China.

出版信息

Nutrition. 2020 Nov-Dec;79-80:110974. doi: 10.1016/j.nut.2020.110974. Epub 2020 Aug 12.

DOI:10.1016/j.nut.2020.110974

Abstract

Intermittent fasting (IF) and energy-restricted diets (ERDs) have emerged as dietary approaches to decrease inflammatory status; however, there are no consistent results regarding humans. To achieve a comprehensive conclusion, we aimed to conduct a meta-analysis of randomized control trials (RCTs) to evaluate the effects of IF or ERDs on plasma concentrations of inflammatory biomarkers. We systematically searched online medical databases including Web of Sciences, PubMed, SCOPUS, and Google Scholar up to June 2019. Evaluations of effect sizes were described employing in weighted mean difference and 95% confidence intervals from the random-effects model. Eighteen eligible RCTs were included in this meta-analysis. The pooled estimation from the random-effect model showed that IF regimens and ERDs significantly reduced C-reactive protein (CRP) concentrations (WMD: -0.024 mg/dL; 95% CI: -0.044 to -0.005, I = 7.0%). Additionally, IF regimens (WMD: -0.029; 95% CI: -0.058 to -0.000, I = 17.9%) were more effective in reducing CRP levels than ERDs (WMD: -0.001 mg/dL; 95% CI: -0.037 to 0.034, I = 0.0%). Moreover, based on the treatment duration and types of the studies' population, a greater reduction was observed in overweight and obese individuals (WMD: -0.03 mg/dL; 95% CI: -0.05 to 0.01, I = 42.1%), and in treatment duration ≥8 wk (WMD: -0.03 mg/dL; 95% CI: -0.05 to 0.01, I = 0.0%) as well. However, IF and ERDs did not significantly reduced tumor necrosis factor-α (WMD: -0.158 pg/mL; P = 0.549, I = 98.3) and interleukin-6 (IL-6) concentrations (WMD: -0.541 pg/mL; P = 0.080, I = 94.7%). This meta-analysis demonstrated that IF regimens and ERDs may reduce CRP concentrations, particularly in overweight and obese individuals and through a considerable length of intervention (≥2 mo). However, neither dietary model affected the concentrations of tumor necrosis factor-α or interleukin-6.

摘要

间歇性禁食（IF）和能量限制饮食（ERD）已成为降低炎症状态的饮食方法；然而，关于人类的结果并不一致。为了得出全面的结论，我们旨在进行荟萃分析随机对照试验（RCT），以评估 IF 或 ERD 对炎症生物标志物血浆浓度的影响。我们系统地检索了在线医学数据库，包括 Web of Sciences、PubMed、SCOPUS 和 Google Scholar，检索时间截至 2019 年 6 月。使用随机效应模型中的加权均数差和 95%置信区间来描述效应量的评估。本荟萃分析纳入了 18 项符合条件的 RCT。随机效应模型的汇总估计显示，IF 方案和 ERD 可显著降低 C 反应蛋白（CRP）浓度（WMD：-0.024 mg/dL；95%CI：-0.044 至-0.005，I=7.0%）。此外，IF 方案（WMD：-0.029；95%CI：-0.058 至-0.000，I=17.9%）在降低 CRP 水平方面比 ERD 更有效（WMD：-0.001 mg/dL；95%CI：-0.037 至 0.034，I=0.0%）。此外，基于研究人群的治疗持续时间和类型，超重和肥胖个体观察到更大的降低（WMD：-0.03 mg/dL；95%CI：-0.05 至 0.01，I=42.1%），以及治疗持续时间≥8 周（WMD：-0.03 mg/dL；95%CI：-0.05 至 0.01，I=0.0%）也观察到更大的降低。然而，IF 和 ERD 并未显著降低肿瘤坏死因子-α（WMD：-0.158 pg/mL；P=0.549，I=98.3）和白细胞介素-6（IL-6）浓度（WMD：-0.541 pg/mL；P=0.080，I=94.7%）。这项荟萃分析表明，IF 方案和 ERD 可能会降低 CRP 浓度，特别是在超重和肥胖个体中，并通过相当长的干预（≥2 个月）。然而，这两种饮食模式都没有影响肿瘤坏死因子-α或白细胞介素-6 的浓度。