Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy.
Pediatric Unit, "V. Buzzi" Children's Hospital, 20153 Milan, Italy.
Biomolecules. 2020 Sep 16;10(9):1324. doi: 10.3390/biom10091324.
Obesity is a growing health problem in both children and adults, impairing physical and mental state and impacting health care system costs in both developed and developing countries. It is well-known that individuals with excessive weight gain frequently develop obesity-related complications, which are mainly known as Non-Communicable Diseases (NCDs), including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, non-alcoholic fatty liver disease, hypertension, hyperlipidemia and many other risk factors proven to be associated with chronic inflammation, causing disability and reduced life expectancy. This review aims to present and discuss complications related to inflammation in pediatric obesity, the critical role of nutrition and diet in obesity-comorbidity prevention and treatment, and the impact of lifestyle. Appropriate early dietary intervention for the management of pediatric overweight and obesity is recommended for overall healthy growth and prevention of comorbidities in adulthood.
肥胖是儿童和成人日益严重的健康问题，损害身心健康，并影响发达国家和发展中国家的医疗保健系统成本。众所周知，体重过度增加的个体经常会出现与肥胖相关的并发症，这些并发症主要被称为非传染性疾病（NCDs），包括心血管疾病、2 型糖尿病、代谢综合征、非酒精性脂肪性肝病、高血压、高血脂和许多其他已被证明与慢性炎症相关的风险因素，导致残疾和预期寿命缩短。本综述旨在介绍和讨论儿科肥胖相关的炎症并发症，营养和饮食在肥胖合并症预防和治疗中的关键作用，以及生活方式的影响。建议对儿童超重和肥胖进行适当的早期饮食干预，以促进整体健康生长，并预防成年后的合并症。
