LightInDerm R&D, Hôpital Cochin, Paris, France.
Matriscience, Hôpital Cochin, Paris, France.
J Biophotonics. 2020 Dec;13(12):e202000230. doi: 10.1002/jbio.202000230. Epub 2020 Oct 5.
Skin structure and function results from a dynamic interplay between dermal and epidermal cell types. Optimizing skin health through an effective and long-lasting skin care regime therefore requires a global approach, encompassing various mechanisms to stimulate this interplay beyond the action scope of a classical topical solution. This study evaluates the impact of a novel home-use device combining a topical serum, light-emitting diodes and massage on the clinical signs of extrinsic skin aging. The innovative principle relies on potentiating the effect of active ingredients contained in the topical serum with visible and near infra-red photons to prevent extracellular matrix degradation and promote its reconstruction. After in vitro and ex vivo investigations, a clinical study assessed the safety and efficacy of a daily treatment with the home-use device for 28 days. A significant increases in skin density and radiance while reducing the wrinkles was obtained with no side effects.
皮肤结构和功能源于真皮和表皮细胞类型之间的动态相互作用。因此，通过有效的、持久的皮肤护理方案来优化皮肤健康需要采取一种全面的方法，涵盖各种刺激这种相互作用的机制，超出经典局部解决方案的作用范围。本研究评估了一种新型家用设备（将局部用血清、发光二极管和按摩相结合）对体外皮肤老化临床体征的影响。创新原理依赖于用可见和近红外光子增强局部用血清中所含活性成分的作用，以防止细胞外基质降解并促进其重建。在体外和离体研究之后，一项临床研究评估了每天使用家用设备治疗 28 天的安全性和有效性。在没有副作用的情况下，皮肤密度和光泽度显著增加，皱纹减少。
