Zhang Huaiyu, Dong Shujun, Li Zhongmin, Feng Xiangru, Xu Weiguo, Tulinao Catrina Mae S, Jiang Yang, Ding Jianxun
Department of Gastrointestinal Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Asian J Pharm Sci. 2020 Jul;15(4):397-415. doi: 10.1016/j.ajps.2019.11.004. Epub 2019 Dec 30.
Over the past decade, nanoparticle-based therapeutic modalities have become promising strategies in cancer therapy. Selective delivery of anticancer drugs to the lesion sites is critical for elimination of the tumor and an improved prognosis. Innovative design and advanced biointerface engineering have promoted the development of various nanocarriers for optimized drug delivery. Keeping in mind the biological framework of the tumor microenvironment, biomembrane-camouflaged nanoplatforms have been a research focus, reflecting their superiority in cancer targeting. In this review, we summarize the development of various biomimetic cell membrane-camouflaged nanoplatforms for cancer-targeted drug delivery, which are classified according to the membranes from different cells. The challenges and opportunities of the advanced biointerface engineering drug delivery nanosystems in cancer therapy are discussed.
在过去十年中，基于纳米颗粒的治疗方式已成为癌症治疗中颇具前景的策略。将抗癌药物选择性递送至病变部位对于消除肿瘤和改善预后至关重要。创新设计和先进的生物界面工程推动了各种用于优化药物递送的纳米载体的发展。考虑到肿瘤微环境的生物学框架，生物膜伪装的纳米平台一直是研究热点，这反映了它们在癌症靶向方面的优势。在本综述中，我们总结了各种用于癌症靶向药物递送的仿生细胞膜伪装纳米平台的发展情况，这些平台根据不同细胞的膜进行分类。讨论了先进生物界面工程药物递送纳米系统在癌症治疗中的挑战与机遇。
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