Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China.
Nanoscale Horiz. 2020 Sep 1;5(9):1293-1302. doi: 10.1039/d0nh00267d. Epub 2020 Jul 1.
The rapid clearance and capture by the immune system pose a big challenge in targeted drug delivery using nanocarriers. Cell membrane coating endows nanoplatforms with prolonged blood circulation, enhanced immune escape, and improved targeting capability. However, monotypic cell membrane fails to meet the omnifarious needs of biomedical applications. The combination of different types of cell membranes provides a promising solution to provide multifunctional biomimetic nanoplatforms. In this review, we first discuss the feasibility of constructing biomimetic hybrid membranes and summarize current methods of preparing biomimetic hybrid membrane-based nanoplatforms (BHMNs) and their biomedical applications including drug delivery, cancer detection, detoxification, and cancer vaccines. Finally, the prospects and challenges of utilizing BHMNs for personalized medicine are also discussed.
免疫清除和捕获的快速性给基于纳米载体的靶向药物输送带来了巨大的挑战。细胞膜包覆赋予纳米平台更长的血液循环时间、增强的免疫逃逸和改进的靶向能力。然而，单型细胞膜无法满足生物医学应用的多样化需求。不同类型细胞膜的结合为提供多功能仿生纳米平台提供了一个有前途的解决方案。在这篇综述中，我们首先讨论了构建仿生混合膜的可行性，并总结了当前制备基于仿生混合膜的纳米平台（BHMNs）的方法及其在药物输送、癌症检测、解毒和癌症疫苗等生物医学应用中的应用。最后，还讨论了利用 BHMN 进行个性化医疗的前景和挑战。
