Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China; Institute of Pharmacy & Pharmacology, School of Pharmaceutical Science, University of South China, Hengyang 421001, China.
Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China; Institute of Pharmacy & Pharmacology, School of Pharmaceutical Science, University of South China, Hengyang 421001, China.
Acta Biomater. 2020 Mar 15;105:1-14. doi: 10.1016/j.actbio.2020.01.036. Epub 2020 Jan 28.
The translocation of natural cell membranes to the surface of synthetic nanoparticles, which allows man-made vectors to share merits and functionalities created by nature, has been a hot subject of research in the past decade. The resulting biomimetic nanoparticles not only retain the physicochemical properties of nanomaterials, but also inherit the advantageous functions of source cells. Combined with the preponderances of both synthetic and natural platforms, the optimized biomimetic systems can maximize the drug delivery efficiency. In this review, we first summarize the preparation strategies of the biomimetic systems from the perspective of the correlation between the properties of nanoparticles and cell membranes. Six types of cell membrane-camouflaged nanoparticles are further introduced with an emphasis on their properties and performance. Finally, a concluding remark regarding the primary challenges and opportunities associated with these nanoparticles is presented. STATEMENT OF SIGNIFICANCE: Translocation of natural cell membranes to the surface of synthetic nanoparticles has been repeatedly highlighted in the past decade to endow man-made vectors with merits and functionalities created by nature; therefore, the resulting biomimetic systems not only retain the physicochemical properties of nanomaterials but also inherit the biological functions of source cells for efficient drug delivery. To provide a timely review on this hot and rapidly developing subject of research, this paper summarized recent progress on the cell membrane-camouflaged nanoparticles as drug carriers for cancer therapy, and focused primarily on six different types of cell membrane-coated nanoparticles with an emphasis on the preparation strategies from the perspective of the correlation between the properties of nanoparticles and cell membrane.
将天然细胞膜转移到合成纳米粒子的表面，使人工载体能够共享自然界创造的优点和功能，这是过去十年研究的热点。由此产生的仿生纳米粒子不仅保留了纳米材料的物理化学性质，还继承了源细胞的有利功能。将合成和天然平台的优势相结合，优化的仿生系统可以最大限度地提高药物输送效率。在这篇综述中，我们首先从纳米粒子的性质与细胞膜的相关性的角度，总结了仿生系统的制备策略。然后，进一步介绍了六种细胞膜伪装的纳米粒子，重点介绍了它们的性质和性能。最后，对这些纳米粒子存在的主要挑战和机遇提出了看法。
在过去的十年中，人们反复强调将天然细胞膜转移到合成纳米粒子的表面，以使人工载体能够获得自然界创造的优点和功能；因此，由此产生的仿生系统不仅保留了纳米材料的物理化学性质，还继承了源细胞的生物功能，以实现高效的药物输送。为了及时对这一热门且快速发展的研究课题进行综述，本文总结了近年来作为癌症治疗药物载体的细胞膜伪装纳米粒子的最新进展，主要关注了六种不同类型的细胞膜包覆纳米粒子，重点介绍了从纳米粒子性质与细胞膜相关性的角度出发的制备策略。
