Sánchez-González José-María, De-Hita-Cantalejo Concepción, Sánchez-González María Carmen
Department of Physics of Condensed Matter, Optics Area, University of Seville, Seville 41012, Spain.
Int J Ophthalmol. 2020 Sep 18;13(9):1368-1373. doi: 10.18240/ijo.2020.09.05. eCollection 2020.
To study the effect of uncrosslinked and crosslinked hyaluronic acid combined with other artificial tear components in patients with dry eye caused by moderate meibomian gland dysfunction.
Prospective, single-blind, contralateral eye study. Fifty eyes (25 patients) were analyzed. Eye selection for each tear type was random, and the eye drop formulations, 0.4% uncrosslinked hyaluronic acid and 0.2% galactoxyloglucan (tear A) and 0.15% crosslinked hyaluronic acid, crocin, and liposomes (tear B) were used. The determined dosing schedule was three times a day for six weeks, and the study participants underwent a clinical examination before and 45d after lubricant treatment. The Schirmer test, tear breakup time (TBUT) test, and Ocular Surface Disease Index (OSDI) questionnaire were applied before and after instillation period with both types of artificial tears.
On the Schirmer test, a significant improvement was obtained with both tear A (<0.01) and tear B (<0.01). On the TBUT test, a significant improvement was obtained with tear A (<0.01) and tear B (<0.01). The OSDI score significantly decreased after instillation period with both artificial tear types (<0.01).
Uncrosslinked hyaluronic acid combined with other components, such as tamarind seed polysaccharide, and crosslinked hyaluronic acid combined with liposomes and crocin are effective for management symptoms of dry eye disease.
研究未交联和交联透明质酸与其他人工泪液成分联合应用于中度睑板腺功能障碍所致干眼症患者的效果。
前瞻性、单盲、对侧眼研究。分析了50只眼（25例患者）。每种泪液类型的眼别选择是随机的，使用的滴眼液配方为0.4%未交联透明质酸和0.2%半乳甘露聚糖（泪液A）以及0.15%交联透明质酸、藏红花素和脂质体（泪液B）。确定的给药方案是每天3次，持续6周，研究参与者在润滑剂治疗前和治疗后45天接受临床检查。在两种人工泪液滴注期前后均应用了泪液分泌试验、泪膜破裂时间（TBUT）试验和眼表疾病指数（OSDI）问卷。
在泪液分泌试验中，泪液A（<0.01）和泪液B（<0.01）均取得显著改善。在TBUT试验中，泪液A（<0.01）和泪液B（<0.01）均取得显著改善。两种人工泪液滴注期后OSDI评分均显著降低（<0.01）。
未交联透明质酸与其他成分（如罗望子种子多糖）联合应用以及交联透明质酸与脂质体和藏红花素联合应用对干眼症症状的管理有效。
