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A platform for phenotyping disease progression and associated longitudinal risk factors in large-scale EHRs, with application to incident diabetes complications in the UK Biobank.一个用于在大规模电子健康记录中对疾病进展及相关纵向风险因素进行表型分析的平台,并应用于英国生物银行中的新发糖尿病并发症研究。
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Predicting diabetic nephropathy in type 2 diabetic patients using machine learning algorithms.使用机器学习算法预测2型糖尿病患者的糖尿病肾病
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Heterogeneous treatment effects of intensive glycemic control on major adverse cardiovascular events in the ACCORD and VADT trials: a machine-learning analysis.强化血糖控制对 ACCORD 和 VADT 试验中主要不良心血管事件的异质性治疗效果:机器学习分析。
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本文引用的文献

1
Effects of intensive glucose control on microvascular outcomes in patients with type 2 diabetes: a meta-analysis of individual participant data from randomised controlled trials.强化血糖控制对 2 型糖尿病患者微血管结局的影响:来自随机对照试验的个体参与者数据的荟萃分析。
Lancet Diabetes Endocrinol. 2017 Jun;5(6):431-437. doi: 10.1016/S2213-8587(17)30104-3. Epub 2017 Mar 30.
2
Long-term Glycemic Variability and Risk of Adverse Outcomes: A Systematic Review and Meta-analysis.长期血糖变异性与不良结局风险:系统评价和荟萃分析。
Diabetes Care. 2015 Dec;38(12):2354-69. doi: 10.2337/dc15-1188.
3
Visit-to-visit variability of blood pressure and cardiovascular disease and all-cause mortality: a systematic review and meta-analysis.血压变异性与心血管疾病及全因死亡率的关系:系统评价和荟萃分析。
Hypertension. 2014 Nov;64(5):965-82. doi: 10.1161/HYPERTENSIONAHA.114.03903. Epub 2014 Jul 28.
4
Impact of visit-to-visit glycemic variability on the risks of macrovascular and microvascular events and all-cause mortality in type 2 diabetes: the ADVANCE trial.在 2 型糖尿病中,血糖变异性对大血管和微血管事件及全因死亡率的影响: ADVANCE 试验。
Diabetes Care. 2014 Aug;37(8):2359-65. doi: 10.2337/dc14-0199. Epub 2014 May 8.
5
Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial.强化血糖控制对 2 型糖尿病患者微血管结局的影响:ACCORD 随机试验分析。
Lancet. 2010 Aug 7;376(9739):419-30. doi: 10.1016/S0140-6736(10)60576-4. Epub 2010 Jun 30.
6
Glucose control and vascular complications in veterans with type 2 diabetes.2型糖尿病退伍军人的血糖控制与血管并发症
N Engl J Med. 2009 Jan 8;360(2):129-39. doi: 10.1056/NEJMoa0808431. Epub 2008 Dec 17.
7
Effects of intensive glucose lowering in type 2 diabetes.强化降糖对2型糖尿病的影响。
N Engl J Med. 2008 Jun 12;358(24):2545-59. doi: 10.1056/NEJMoa0802743. Epub 2008 Jun 6.
8
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.磺脲类或胰岛素强化血糖控制与传统治疗及2型糖尿病患者并发症风险的比较(英国前瞻性糖尿病研究[UKPDS 33])。英国前瞻性糖尿病研究(UKPDS)小组
Lancet. 1998 Sep 12;352(9131):837-53.

Long-term glucose variability and risk of nephropathy complication in UKPDS, ACCORD and VADT trials.

作者信息

Zhou Jin J, Coleman Ruth, Holman Rury R, Reaven Peter

机构信息

Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.

Carl T. Hayden Phoenix VA Health Care System (111E), Phoenix, AZ, USA.

出版信息

Diabetologia. 2020 Nov;63(11):2482-2485. doi: 10.1007/s00125-020-05273-7. Epub 2020 Sep 21.

DOI:10.1007/s00125-020-05273-7
PMID:32954444
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7573923/
Abstract
摘要