聚乳酸的纳米、微颗粒和化妆品传递系统：小型综述。
Nano, micro particulate and cosmetic delivery systems of polylactic acid: A mini review.
机构信息
Department of Cosmetic Science, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan.
Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan.
出版信息
J Cosmet Dermatol. 2020 Nov;19(11):2805-2811. doi: 10.1111/jocd.13696. Epub 2020 Sep 21.
BACKGROUND
Poly lactic acid and its copolymers are considered to be the preferred substrates for drug delivery devices. Poly lactic acid is a biocompatible, biodegradable and nontoxic polymer. It was approved by Food and Drug Administration and thought to be among the most attractive polymeric candidates intended for controlling drug delivery. It was utilized for the development of devices for the delivery of small molecules, proteins, genes, vaccines, anticancer drugs, and macromolecules.
OBJECTIVES AND METHODS
This manuscript lists the different techniques for synthesizing poly lactic acid-based nano and microparticles such as emulsion-based methods, precipitation-based methods, direct compositing methods, in situ forming micro-particles, and microfluidic technique.
CONCLUSIONS
In addition, it describes the application and use of poly lactic acid in biomedical and cosmetic delivery systems.
背景
聚乳酸及其共聚物被认为是药物输送装置的首选基质。聚乳酸是一种生物相容性、可生物降解和无毒的聚合物。它已获得美国食品和药物管理局的批准，被认为是最具吸引力的聚合物候选材料之一，旨在控制药物输送。它被用于开发用于输送小分子、蛋白质、基因、疫苗、抗癌药物和大分子的装置。
目的和方法
本文列出了合成基于聚乳酸的纳米和微米粒子的不同技术，如乳液法、沉淀法、直接复合法、原位形成微粒子和微流控技术。
结论
此外，它描述了聚乳酸在生物医学和化妆品输送系统中的应用和用途。
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