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电化学生物传感器和纳米生物传感器的当前进展

Current Advances in Electrochemical Biosensors and Nanobiosensors.

作者信息

Bakirhan Nurgul K, Topal Burcu D, Ozcelikay Goksu, Karadurmus Leyla, Ozkan Sibel A

机构信息

Department of Analytical Chemistry, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara, Turkey.

Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey.

出版信息

Crit Rev Anal Chem. 2022;52(3):519-534. doi: 10.1080/10408347.2020.1809339. Epub 2020 Sep 20.

Abstract

Electrochemical biosensors have wider interest in the last decades than other analytical techniques such as chromatography, spectrophotometry, fluorescence, migration techniques and flow systems. Since they provide practicality, sensitivity, and fast response, these systems can be integrated with labs-on-chips to obtain excellent point of care analytical platforms. They are excellent devices for wide range of analytes such as drugs, proteins, markers, bacteria, and viruses etc. due to their unique features. Electrochemical methods are also successful at molecular recognition, user friendliness, sensitive responses, requirement of small volume reactive of reagents, low cost, and applicability to point of care tests. DNA, enzyme and immunosensor based biosensors are widely used as well. According to recent studies of electrochemical biosensors, nanomaterials and polymers have been used to increase the performance of biosensors. In this review, the recent studies of electrochemical biosensors have been presented with their applications at various fields.

摘要

在过去几十年中,电化学生物传感器比其他分析技术(如色谱法、分光光度法、荧光法、迁移技术和流动系统)更受关注。由于它们具有实用性、灵敏度和快速响应性,这些系统可以与芯片实验室集成,以获得出色的即时护理分析平台。由于其独特的特性,它们是用于检测多种分析物(如药物、蛋白质、标志物、细菌和病毒等)的优秀设备。电化学方法在分子识别、用户友好性、灵敏响应、试剂反应所需体积小、成本低以及适用于即时护理测试方面也很成功。基于DNA、酶和免疫传感器的生物传感器也被广泛使用。根据最近对电化学生物传感器的研究,纳米材料和聚合物已被用于提高生物传感器的性能。在这篇综述中,介绍了电化学生物传感器的最新研究及其在各个领域的应用。

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