Department of Joint Surgery, 74768Tianjin Hospital, Tianjin, People's Republic of China.
Department of Joint Surgery, Yuhuangding Hospital, Yantai, Shandong, People's Republic of China.
J Orthop Surg (Hong Kong). 2020 Sep-Dec;28(3):2309499020959158. doi: 10.1177/2309499020959158.
The aim was to compare the efficacy and safety of epsilon-aminocaproic acid (EACA) and tranexamic acid (TXA) in total hip arthroplasty (THA) and total knee arthroplasty (TKA).
Potential academic articles were identified from the Cochrane Library, Springer, PubMed, and ScienceDirect databases from inception to December 2019. Randomized controlled trials (RCTs) and non-RCTs involving EACA and TXA in THA or TKA were included. Pooled data were analyzed using RevMan 5.1.
Three RCTs and three non-RCTs met the inclusion criteria. The present meta-analysis reveals that EACA is associated with significantly more blood loss than TXA. No significant differences were identified in terms of blood transfusion rate, transfusion units, hemoglobin (Hb) level at discharge, operation time, length of hospital stay, deep venous thrombosis (DVT), or 30-day readmission.
Compared with TXA, EACA led to more blood loss in patients undergoing THA or TKA. However, there was no significant difference in the blood transfusion rate, transfusion units, Hb level at discharge, operation time, length of hospital stay, DVT, or 30-day readmission between groups.
本研究旨在比较氨甲环酸（EACA）和氨甲环酸（TXA）在全髋关节置换术（THA）和全膝关节置换术（TKA）中的疗效和安全性。
从 Cochrane Library、Springer、PubMed 和 ScienceDirect 数据库中检索了从建库至 2019 年 12 月的潜在学术文章。纳入了涉及 EACA 和 TXA 在 THA 或 TKA 中的随机对照试验（RCT）和非随机对照试验。使用 RevMan 5.1 对汇总数据进行分析。
有三项 RCT 和三项非 RCT 符合纳入标准。本荟萃分析表明，EACA 与 TXA 相比，失血明显更多。输血率、输血量、出院时血红蛋白（Hb）水平、手术时间、住院时间、深静脉血栓形成（DVT）或 30 天再入院率方面无显著差异。
与 TXA 相比，EACA 导致接受 THA 或 TKA 的患者失血更多。然而，两组之间的输血率、输血量、出院时 Hb 水平、手术时间、住院时间、DVT 或 30 天再入院率没有显著差异。
