Geyer H, Braun A
Onkologie. 1987 Apr;10(2):79-82. doi: 10.1159/000216377.
The nuclear estrogen receptors ERn were determined in 12 carcinomas whose cytoplasm contained progesterone receptors PRc but no estrogen receptors ERc. ERn were found in 9 of the tumors. Their concentration correlated to those of PRc and reached a mean of only 20% of the ERn concentrations found in ERc+/PRc + carcinomas. These results suggest that in carcinomas of the ERc-/PRc+-type, originally present cytoplasmic estrogen receptors induce the synthesis of progesterone receptors in a concentration corresponding to that of the nuclear receptors, following translocation by endogenous estradiol in the nucleus.
在12例细胞质中含有孕激素受体（PRc）但无雌激素受体（ERc）的癌组织中检测了核雌激素受体（ERn）。在9例肿瘤中发现了ERn。它们的浓度与PRc的浓度相关，平均仅达到ERc+/PRc +癌组织中ERn浓度的20%。这些结果表明，在ERc-/PRc+-型癌中，原本存在的细胞质雌激素受体在细胞核内被内源性雌二醇转运后，以与核受体浓度相对应的浓度诱导孕激素受体的合成。
