Mohammed Lazo Jazaa, Omer Khalid M
Department of Chemistry, College of Science, University of Sulaimani, Qliasan Street, Sulaimani City, Kurdistan Region, 46002,, Iraq.
Nanoscale Res Lett. 2020 Sep 22;15(1):182. doi: 10.1186/s11671-020-03413-x.
Highly sensitive non-contact mode temperature sensing is substantial for studying fundamental chemical reactions, biological processes, and applications in medical diagnostics. Nanoscale-based thermometers are guaranteeing non-invasive probes for sensitive and precise temperature sensing with subcellular resolution. Fluorescence-based temperature sensors have shown great capacity since they operate as "non-contact" mode and offer the dual functions of cellular imaging and sensing the temperature at the molecular level. Advancements in nanomaterials and nanotechnology have led to the development of novel sensors, such as nanothermometers (novel temperature-sensing materials with a high spatial resolution at the nanoscale). Such nanothermometers have been developed using different platforms such as fluorescent proteins, organic compounds, metal nanoparticles, rare-earth-doped nanoparticles, and semiconductor quantum dots. Carbon dots (CDs) have attracted interest in many research fields because of outstanding properties such as strong fluorescence, photobleaching resistance, chemical stability, low-cost precursors, low toxicity, and biocompatibility. Recent reports showed the thermal-sensing behavior of some CDs that make them an alternative to other nanomaterials-based thermometers. This kind of luminescent-based thermometer is promising for nanocavity temperature sensing and thermal mapping to grasp a better understanding of biological processes. With CDs still in its early stages as nanoscale-based material for thermal sensing, in this review, we provide a comprehensive understanding of this novel nanothermometer, methods of functionalization to enhance thermal sensitivity and resolution, and mechanism of the thermal sensing behavior.
高灵敏度非接触式温度传感对于研究基础化学反应、生物过程以及医学诊断应用至关重要。基于纳米尺度的温度计能够确保实现具有亚细胞分辨率的灵敏且精确的非侵入式温度传感探头。基于荧光的温度传感器展现出了巨大潜力,因为它们以“非接触”模式运行,并提供细胞成像和分子水平温度传感的双重功能。纳米材料和纳米技术的进步推动了新型传感器的发展,例如纳米温度计(具有纳米级高空间分辨率的新型温度传感材料)。此类纳米温度计已通过不同平台开发而成,如荧光蛋白、有机化合物、金属纳米颗粒、稀土掺杂纳米颗粒以及半导体量子点。碳点(CDs)因其具有强荧光、抗光漂白、化学稳定性、低成本前驱体、低毒性和生物相容性等优异特性,在许多研究领域引起了关注。最近的报告展示了一些碳点的热传感行为,这使其成为基于其他纳米材料的温度计的替代品。这种基于发光的温度计有望用于纳米腔温度传感和热成像,以更好地理解生物过程。鉴于碳点作为基于纳米尺度的热传感材料仍处于早期阶段,在本综述中,我们全面介绍了这种新型纳米温度计、增强热灵敏度和分辨率的功能化方法以及热传感行为的机制。