Norwich Medical School, University of East Anglia, Norwich, United Kingdom.
Department of Psychology, University of East Anglia, Norwich, United Kingdom.
PLoS One. 2020 Sep 22;15(9):e0239077. doi: 10.1371/journal.pone.0239077. eCollection 2020.
The Virtual Supermarket Task (VST) and Sea Hero Quest detect high-genetic-risk Alzheimer`s disease (AD). We aimed to determine their test-retest reliability in a preclinical AD population. Over two time points, separated by an 18-month period, 59 cognitively healthy individuals underwent a neuropsychological and spatial navigation assessment. At baseline, participants were classified as low-genetic-risk of AD or high-genetic-risk of AD. We calculated two-way mixed effects intraclass correlation coefficients (ICC) for task parameters and used repeated measures ANOVAS to determine whether genetic risk or sex contributed to test-retest variability. The egocentric parameter of the VST measure showed the highest test-retest reliability (ICC = .72), followed by the SHQ distance travelled parameter (ICC = .50). Post hoc longitudinal analysis showed that boundary-based navigation predicts worsening episodic memory concerns in high-risk (F = 5.01, P = 0.03), but in not low-risk, AD candidates. The VST and the Sea Hero Quest produced parameters with acceptable test-retest reliability. Further research in larger sample sizes is desirable.
虚拟超市任务 (VST) 和海英雄任务检测高遗传风险的阿尔茨海默病 (AD)。我们旨在确定它们在临床前 AD 人群中的测试-重测可靠性。在两个时间点，间隔 18 个月，59 名认知健康的个体接受了神经心理学和空间导航评估。在基线时，参与者被分为 AD 的低遗传风险或高遗传风险。我们为任务参数计算了双向混合效应组内相关系数 (ICC)，并使用重复测量 ANOVA 来确定遗传风险或性别是否导致测试-重测的变异性。VST 测量的以自我为中心的参数显示出最高的测试-重测可靠性 (ICC =.72)，其次是 SHQ 行驶距离参数 (ICC =.50)。事后纵向分析表明，基于边界的导航预测高风险 (F = 5.01, P = 0.03)，而不是低风险 AD 候选者的情景记忆问题恶化。VST 和海英雄任务产生了具有可接受的测试-重测可靠性的参数。在更大的样本量中进行进一步的研究是可取的。
