Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA; Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
Curr Opin Cell Biol. 2021 Feb;68:28-36. doi: 10.1016/j.ceb.2020.08.014. Epub 2020 Sep 19.
Mitochondria form networks that continually remodel and adapt to carry out their cellular function. The mitochondrial network is remodeled through changes in mitochondrial morphology, number, and distribution within the cell. Mitochondrial dynamics depend directly on fission, fusion, shape transition, and transport or tethering along the cytoskeleton. Over the past several years, many of the mechanisms underlying these processes have been uncovered. It has become clear that each process is precisely and contextually regulated within the cell. Here, we discuss the mechanisms regulating each aspect of mitochondrial dynamics, which together shape the network as a whole.
线粒体形成网络，不断重塑和适应以发挥其细胞功能。线粒体网络通过线粒体形态、数量和在细胞内分布的变化进行重塑。线粒体动力学直接依赖于分裂、融合、形状转换以及沿着细胞骨架的运输或连接。在过去的几年中，这些过程的许多机制已经被揭示出来。很明显，每个过程都在细胞内被精确地和上下文地调节。在这里，我们讨论调节线粒体动力学各个方面的机制，这些机制共同塑造了整个网络。
